Baker's yeast-mediated transformations of α-keto epoxides
- O. Meth–Cohn, R. Horak, G. Fouche
- Chemistry
- 1994
αβ-Epoxy ketones on treatment with baker's yeast yield different types of products depending on their substitution. Small groups such as H or Me attached at the epoxy end protect that end from…
Convenient Synthesis of Furo[3,2-b]quinolin-4(1H)-ones
- V. Králová, M. Soural, R. Horak, P. Hradil
- Chemistry
- 1 June 2020
In this work, we report the simple synthesis of furo[3,2-b]quinolin-4(1H)-ones from readily available 4-ethynyl-[1,3]dioxolo[4,5-c]quinolone as the key starting material. After Sonogashira…
Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate.
- D. Cane, J. L. Pawlak, R. Horak
- ChemistryBiochemistry
- 12 June 1990
Two enantiomeric analogues of farnesyl pyrophosphate (1) were tested as inhibitors and anomalous substrates of trichodiene synthase, which catalyzes the cyclization of trans,trans-farnesyl…
Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents
- R. Horak, Lubomír Kvapil, M. Soural
- Chemistry
- 11 January 2018
Alkyl glycosides as potential anti-Candida albicans growth agents
- Tomáš Klunda, E. Machová, Alžzbeta Čížzová, R. Horak, M. Poláková, S. Bystrický
- Chemistry, BiologyChemické zvesti
- 29 December 2016
It was showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida, strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay.
Synthesis of modified D-mannose core derivatives and their impact on GH38 α-mannosidases.
- M. Poláková, R. Horak, S. Šesták, I. Holková
- Biology, ChemistryCarbohydrate Research
- 16 June 2016
Synthetic approach to novel glycosyltriazole-3-hydroxyquinolone conjugates and their antimicrobial properties
- V. Šamšulová, M. Poláková, R. Horak, Mária Šedivá, Lubomír Kvapil, P. Hradil
- Chemistry, BiologyJournal of Molecular Structure
- 5 February 2019
An intramolecular C–N cross-coupling of β-enaminones: a simple and efficient way to precursors of some alkaloids of Galipea officinalis
- Hana Doušová, R. Horak, Z. Růžičková, P. Šimůnek
- Chemistry, BiologyBeilstein Journal of Organic Chemistry
- 27 May 2015
A simple and efficient protocol for an intramolecular, palladium or copper-catalysed amination of both chloro- and bromo-substituted 3-amino-1,5-diphenylpent-2-en-1-ones leading to the tetrahydroquinoline moiety is developed.
Structural analogues of quinoline alkaloids: Straightforward route to [1,3]dioxolo[4,5‐ c ]quinolines with antibacterial properties
- R. Horak, K. Kořistek, M. Soural
- Chemistry
- 21 January 2020
The stereocontrolled formation of 1,2,3-triols by yeast-mediated transformation of α-keto epoxides
- G. Fouche, R. Horak, O. Meth–Cohn
- Chemistry
- 1993
3-Phenyl-2,3-epoxy ketones are transformed using baker's yeast into the corresponding 1,2,3-triols as one pure diastereoisomer (S,S,Sand R,R,R) formed by syn ring opening of the epoxide after first…
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