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COPD prevalence is increased in lung cancer, independent of age, sex and smoking history
Chronic obstructive pulmonary disease (COPD) is a common comorbid disease in lung cancer, estimated to affect 40–70% of lung cancer patients, depending on diagnostic criteria. As smoking exposure isExpand
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Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function.
BACKGROUND Chronic obstructive pulmonary disease (COPD) is predominantly the consequence of chronic smoking exposure, but its development may be influenced by genetic variants that affect lungExpand
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Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease.
BACKGROUND Only a few long term smokers develop symptomatic chronic obstructive pulmonary disease (COPD) and this may be due, at least in part, to genetic susceptibility to the disease. TransformingExpand
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Lung cancer gene associated with COPD: triple whammy or possible confounding effect?
Recently, several large genome-wide association studies have identified a putative “lung cancer” locus in the nicotinic acetylcholine receptor subunit genes (nAChR) on 15q25. However, these findingsExpand
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Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes
The clinical utility of spirometric screening of asymptomatic smokers for early signs of air flow limitation has recently come under review. The current authors propose that reduced forced expiratoryExpand
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Transforming growth factor-β1 genotype and susceptibility to chronic obstructive pulmonary disease
Background: Only a few long term smokers develop symptomatic chronic obstructive pulmonary disease (COPD) and this may be due, at least in part, to genetic susceptibility to the disease. TransformingExpand
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Chromosome 4q31 locus in COPD is also associated with lung cancer
Chronic obstructive pulmonary disease (COPD) is the single greatest risk factor for lung cancer in smokers and is found in 50–90% of lung cancer cases. The link between COPD and lung cancer may stemExpand
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Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities
Chronic obstructive pulmonary disease (COPD) is soon to become the third leading cause of death in developed countries. COPD is increasingly considered a multisystem disease characterized by bothExpand
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Pharmacological actions of statins: potential utility in COPD
Chronic obstructive pulmonary disease (COPD) is characterised by minimally reversible airflow limitation and features of systemic inflammation. Current therapies for COPD have been shown to reduceExpand
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Individual and Cumulative Effects of GWAS Susceptibility Loci in Lung Cancer: Associations after Sub-Phenotyping for COPD
Epidemiological studies show that approximately 20–30% of chronic smokers develop chronic obstructive pulmonary disease (COPD) while 10–15% develop lung cancer. COPD pre-exists lung cancer in 50–90%Expand
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