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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
TLDR
Four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer were identified and confirmed in 1,776 affected individuals and 2,072 controls from three additional studies. Expand
Migration patterns and breast cancer risk in Asian-American women.
TLDR
Exposure to Western lifestyles had a substantial impact on breast cancer risk in Asian migrants to the United States during their lifetime, and this study should provide new insights into the etiology of breast cancer. Expand
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
TLDR
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295. Expand
Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study.
TLDR
Novel molecular markers are needed to better predict progression to MM in patients with MGUS and in approximately half the study population, the M-protein concentration and involved FLC-ratio levels showed a yearly increase prior to MM diagnosis. Expand
Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk.
TLDR
The data suggest that the estrogen-progestin regimen increases breast cancer risk beyond that associated with estrogen alone, and were evident for the majority of invasive tumors with ductal histology and regardless of extent of invasive disease. Expand
Multiple loci identified in a genome-wide association study of prostate cancer
TLDR
The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals. Expand
Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study.
TLDR
It is concluded that factors associated with altered immunity and T-cell regulatory mechanisms are predictors of both early- and late-onset PTLD. Expand
Mammographic features and breast cancer risk: effects with time, age, and menopause status.
TLDR
M mammographic features were associated with known breast cancer risk factors, however, the high-density parenchymal pattern effects were independent of family history, age at first birth, alcohol consumption, and benign breast disease. Expand
Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men
TLDR
In older men, and in younger men with pre-existing diagnosed heart disease, the risk of MI following initiation of TT prescription is substantially increased. Expand
A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
TLDR
A multi-stage genome-wide association study of natural hair color in more than 10,000 men and women of European ancestry from the United States and Australia suggests that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. Expand
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