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A closed tube format for amplification and detection of DNA based on energy transfer.
A new method for the direct detection of PCR-amplified DNA in a closed system is described. The method is based on the incorporation of energy transfer-labeled primers into the amplification product.… Expand
The receptor with high affinity for immunoglobulin E.
- H. Metzger, G. Alcaraz, R. Hohman, J. P. Kinet, V. Pribluda, R. Quarto
- Biology, Medicine
- Annual review of immunology
This review is about one of the physiologically important macromolecules that interact with the Fc domains of immunoglobulins. Such substances (complement, "immunoglobulin binding factors," Fc… Expand
Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.
- T. Hultsch, M. W. Albers, S. Schreiber, R. Hohman
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 July 1991
Investigations of the actions and interactions of the immunophilin ligands FK506, cyclosporin A (CsA), rapamycin, and 506BD suggest that complexes of FK506 with an FK506-binding protein or of CsA… Expand
Phospholipase C-gamma 1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors.
Aggregation of the high affinity receptor for IgE (Fc epsilon RI) on the surface of mast cells results in the rapid hydrolysis of membrane inositol phospholipids by phospholipase C (PLC). Although at… Expand
Detection of telomerase activity utilizing energy transfer primers: comparison with gel- and ELISA-based detection.
We have developed a closed-tube format telomeric repeat amplification protocol (TRAP) assay for direct quantification of telomerase activity within the PCR vessel. The assay utilizes energy transfer… Expand
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy…
- K. Maeyama, R. Hohman, H. Metzger, M. Beaven
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 February 1986
RBL-2H3 cells (a tumor analog of rat mast cells) have plasma-membrane receptors that bind immunoglobulin E, which when aggregated, initiate degranulation. As in other systems, secretion is preceeded… Expand
Substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients.
- B. Mosimann, M. White, R. Hohman, M. Goldrich, H. Kaulbach, M. Kaliner
- The Journal of allergy and clinical immunology
- 1 July 1993
BACKGROUND There is suggestive evidence that neuropeptides participate in allergic reactions. Substance P (SP) and calcitonin gene-related peptide (CGRP) are released by sensory nerves, whereas… Expand
Distribution of secretory leukoprotease inhibitor in the human nasal airway.
- C. Lee, Y. Igarashi, R. Hohman, H. Kaulbach, M. White, M. Kaliner
- The American review of respiratory disease
- 1 March 1993
Secretory leukoprotease inhibitor (SLPI) is a secreted glandular protein thought to regulate elastase activity and, more recently, to inhibit both mast cell chymase activity and histamine release… Expand
ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans
- J. Lyons, Y. Liu, +22 authors J. Milner
- Medicine, Biology
- The Journal of experimental medicine
- 6 March 2017
Nonimmunological connective tissue phenotypes in humans are common among some congenital and acquired allergic diseases. Several of these congenital disorders have been associated with either… Expand
S‐Adenosyl‐L‐homocysteine hydrolase from Dictyostelium discoideum is inactivated by cAMP and reactivated by NAD+
Purified S‐adenosyl‐L‐homocysteine hydrolase from Dictyostelium discoideum is inactivated when incubated at 25°C with cAMP. Half maximal velocity of the inactivation process occurs at 10 μM cAMP.… Expand