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Symptom Assessment in Schizophrenic Prodromal States
The Structured Interview for Prodromal Symptoms and the Scale of Prodromaal Symptoms are assessment instruments developed for operationally defining diagnosis and for quantitatively rating symptom severity for patients prodromal for psychosis.
Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations.
- R. Hoffman, K. Hawkins, +4 authors J. Krystal
- Psychology, MedicineArchives of general psychiatry
Auditory hallucinations were robustly improved with rTMS relative to sham stimulation, and the mechanism of AHs involves activation of the left temporoparietal cortex, which suggests that one-hertz rT MS deserves additional study as a possible treatment for this syndrome.
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
- J. Krystal, D. D’Souza, D. Mathalon, E. Perry, A. Belger, R. Hoffman
- Psychology, MedicinePsychopharmacology
- 2 September 2003
It is considered the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia.
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
- T. McGlashan, R. Zipursky, +12 authors A. Breier
- Psychology, MedicineThe American journal of psychiatry
- 1 May 2006
The nearly significant differences suggest that olanzapine might reduce the conversion rate and delay onset of psychosis, and was efficacious for positive prodromal symptoms but induced weight gain.
The Gene Wars: Science, Politics, and the Human Genome
- R. Hoffman
- 1 July 1996
Come with us to read a new book that is coming recently. Yeah, this is a new coming book that many people really want to read will you be one of them? Of course, you should be. It will not make you…
A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression
- R. Berman, M. Narasimhan, +5 authors N. Boutros
- Psychology, MedicineBiological Psychiatry
- 15 February 2000
A 2-week course of active rT MS resulted in statistically significant but clinically modest reductions of depressive symptoms, as compared to sham rTMS in a population characterized by treatment resistance.
Schizophrenia as a disorder of developmentally reduced synaptic connectivity.
A computer simulation of the elimination of the synaptic connections that models normal cognitive development and psychotic symptom formation is reviewed and some of the model's predictions and questions raised for basic research, early detection, and preventive intervention are discussed.
Verbal hallucinations and language production processes in schizophrenia
- R. Hoffman
- 1 September 1986
How is it that many schizophrenics identify certain instances of verbal imagery as hallucinatory? Most investigators have assumed that alterations in sensory features of imagery explain this. This…
Transcranial magnetic stimulation and auditory hallucinations in schizophrenia
- R. Hoffman, N. Boutros, Sylvia Hu, R. Berman, J. Krystal, D. Charney
- MedicineThe Lancet
- 25 March 2000
12 patients with schizophrenia and auditory hallucinations received 1 Hz transcranial magnetic stimulation of left temporoparietial cortex. In a double-blind crossover trial, active stimulation…