R. Hoffman

Publications587
h-index58
Citations11,766
Highly Influential Citations338
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Body packing--the internal concealment of illicit drugs.
The transportation of illicit drugs by concealment within the body is now a common practice, and it has implications for clinical care. Body packers may ingest dozens of packets containing… Expand
Nerve Agents: A Comprehensive Review
TLDR
Nerve agents are perhaps the most feared of potential agents of chemical attack and the history, physical characteristics, pharmacology, clinical effects, and treatment are reviewed. Expand
Goldfrank's Manual of Toxicologic Emergencies
General Approach to Medical Toxicology: Tools of the Trade The Biochemical, Molecular, and Pathophysiologic Basis of Medical Toxicology The Clinical Basis of Medical Toxicology Pharmaceuticals… Expand
National academy of clinical biochemistry laboratory medicine practice guidelines: recommendations for the use of laboratory tests to support poisoned patients who present to the emergency department.
TLDR
Recommendations for the use of clinical laboratory tests were prepared by an expert panel of analytical toxicologists and ED physicians specializing in clinical toxicology, and improvements are needed for immunoassays, particularly for amphetamines, benzodiazepines, opioids, and tricyclic antidepressants. Expand
Levamisole in cocaine: Unexpected news from an old acquaintance
TLDR
The importance of accurately identifying levamisole-induced complications is therefore critical for symptomatic patients as discontinuation of exposure is fundamental and as a correct diagnosis prevents unnecessary and potentially dangerous use of other treatment modalities like powerful immunosuppressive therapy. Expand
Severe Toxicity Following Synthetic Cannabinoid Ingestion
TLDR
Ingestion of JWH-018 can produce seizures and tachyarrhythmias, and Clinicians, lawmakers, and the general public need to be aware of the potential for toxicity associated with synthetic cannabinoid use. Expand
Resistant alcohol withdrawal: Does an unexpectedly large sedative requirement identify these patients early?
TLDR
RAW patients require large doses of benzodiazepine administration, additional sedatives, and undergo complicated hospitalizations, according to physicians’ choices of therapy. Expand
Extracorporeal Treatment for Lithium Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
TLDR
The workgroup concluded that lithium is dialyzable (Level of evidence=A) and made the following recommendations: Hemodialysis is the preferred extracorporeal treatment, but continuous RRT is an acceptable alternative (1D). Expand
Osmol gaps revisited: normal values and limitations.
TLDR
The osmol gap in patients whose serum ethanol concentrations are known, to reevaluate several accepted equations for calculating osmolarity, and to apply the results to the theoretical clinical scenario of a toxic alcohol ingestion is defined. Expand
Administration of purified human plasma cholinesterase protects against cocaine toxicity in mice.
TLDR
Pretreatment with purified human plasma cholinesterase protects mice against the convulsive and lethal effects of cocaine. Expand
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