• Publications
  • Influence
Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle
TLDR
The genome of one of the three known single-stranded circular DNA viruses has been completely analyzed for the first time, and it is shown that the CAV genome probably contains only one promoter region and only one poly(A) addition signal. Expand
Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.
TLDR
The 911 cell line is demonstrated to have several characteristics in common with the well-known 293 cell line, which make it a useful alternative for the construction, propagation, and titration of E1-deleted recombinant adenoviruses. Expand
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
TLDR
Mutation of TBC1d1 suppresses high-fat diet–induced obesity by increasing lipid use in skeletal muscle by results in a truncated protein lacking the TBC Rab–GTPase-activating protein domain. Expand
The adenovirus capsid: major progress in minor proteins.
TLDR
A review of the minor capsid proteins is provided, with a focus on new insights into their position and role in the capsid and the opportunities that they provide for improving human adenovirus-derived gene-delivery vectors. Expand
p16INK4a Is Required for hSNF5 Chromatin Remodeler-induced Cellular Senescence in Malignant Rhabdoid Tumor Cells*
TLDR
Results indicate that in human MRT cells, the p16INK4a/pRb, rather than the p14ARF/p53 pathway, mediates hSNF5-induced cellular senescence. Expand
Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.
TLDR
A comprehensive analysis of the sequences of 34 E1A proteins identifies highly conserved sequences without known activities or binding partners, suggesting that previously unrecognized determinants of E 1A function remain to be uncovered. Expand
Highly Efficient Transduction of Human Monocyte-Derived Dendritic Cells with Subgroup B Fiber-Modified Adenovirus Vectors Enhances Transgene-Encoded Antigen Presentation to Cytotoxic T Cells1
TLDR
Subgroup B fiber-modified rAd5 constitute a major breakthrough in the exploitation of ex vivo rAd-targeted DC as clinically relevant vaccines and may also be suitable for in vivo genetic modification of DC. Expand
Adenovirus DNA replication.
TLDR
The development of antivirals that interfere with human adenovirus replication and the impact of HAdV on human disease are covered. Expand
New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses.
TLDR
The combination of PER.C6 cells and nonoverlapping E1-deleted adenoviral vectors eliminates the problem of RCA generation by homologous recombination, and allows cost-effective production of safe, clinical-grade batches of recombinant Ad vectors. Expand
In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus.
TLDR
It is demonstrated for the first time that the acidic-repeat region of LANA-1 could function as an in cis acting inhibitor of antigen presentation, which may contribute to the immune evasion of cells latently infected by KSHV. Expand
...
1
2
3
4
5
...