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Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine
- C. L. Bregman, R. Hirth, J. Sundberg, E. F. Christensen
- Biology, Medicine
- Veterinary pathology
- 1 November 1987
A spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (COP) vaccine, suggesting a viral etiology for the masses. Lesions included… Expand
Lesions of Spontaneous Subclinical Disease in Beagle Dogs
Postmortem examination of 1000 commercially bred Beagle dogs used in 39 drug-safety evaluations showed a spectrum of concurrent lesions of spontaneous, subclinical disease that was used to develop a… Expand
Gastric Enterochromaffin-Like Cell Hyperplasia and Neoplasia in the Rat: An Indirect Effect of the Histamine H2-Receptor Antagonist, BL-6341
Oral administration of BL-6341 hydrochloride, a long-acting histamine H2-receptor antagonist, to rats for 2 years at doses of 10, 55 or 300 mg/kg/day resulted in several changes in the fundic… Expand
Bovine Salpingo-oophoritis Produced with Semen Containing a Mycoplasma
A Mycoplasma, which was a natural pathogen for the bovine mammary gland was added to bull semen prior to processing and freezing in liquid nitrogen. Twelve virgin heifers were inseminated with frozen… Expand
BR96-Doxorubicin Conjugate (BMS-182248) Versus Doxorubicin: A Comparative Toxicity Assessment in Rats
- C. Comereski, W. Peden, T. Davidson, G. Warner, R. Hirth, J. Frantz
- Toxicologic pathology
- 1 September 1994
The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m2… Expand
Pathology of feline toxoplasmosis.
— —A retrospective pathologic study of sixteen cats with toxoplasmosis revealed that the most consistent lesion was an interstitial pneumonia accompanied by fibrinous exudate, focal necrosis,… Expand
Single-dose and multiple-dose intravenous toxicity studies of BMY-25282 in rats.
- C. L. Bregman, C. Comereski, R. Buroker, R. Hirth, H. Madissoo, G. H. Hottendorf
- Fundamental and applied toxicology : official…
- 1 July 1987
Single-dose and multiple-dose (daily X 5 and weekly X 5) intravenous toxicity studies in rats were conducted to determine the possible acute and delayed toxicity of BMY-25282… Expand
Tallysomycin S10b: Experimental antitumor activity and toxicity
- J. Schurig, W. Rose, +4 authors W. T. Bradner
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
SummaryTallysomycin S10b (TLM S10b), a structural analog of bleomycin (BLM), was evaluated and compared with BLM for antitumor activity in several murine tumor systems and for toxic effects in mice… Expand
The toxicologic evaluation of marcellomycin--an antineoplastic anthracycline antibiotic.
- R. Buroker, D. Johnson, C. Comereski, R. Hirth, H. Madissoo, G. H. Hottendorf
- Drug and chemical toxicology
Dose-related toxicologic effects of marcellomycin, an antineoplastic anthracycline antibiotic, were observed in single-dose studies in mice iv (43.05-67.65 mg/m2) and dogs iv (41.0-90.2 mg/m2), and… Expand
A murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice.
Meningitis and meningoencephalomyelitis caused by Listeria monocytogenes were experimentally established in mice. The pathological changes in brain and spinal cord resulting from the infection… Expand