R. Hirth

Publications37
h-index12
Citations469
Highly Influential Citations17
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Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine
A spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (COP) vaccine, suggesting a viral etiology for the masses. Lesions included… Expand
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Lesions of Spontaneous Subclinical Disease in Beagle Dogs
Postmortem examination of 1000 commercially bred Beagle dogs used in 39 drug-safety evaluations showed a spectrum of concurrent lesions of spontaneous, subclinical disease that was used to develop a… Expand
  • 50
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Gastric Enterochromaffin-Like Cell Hyperplasia and Neoplasia in the Rat: An Indirect Effect of the Histamine H2-Receptor Antagonist, BL-6341
Oral administration of BL-6341 hydrochloride, a long-acting histamine H2-receptor antagonist, to rats for 2 years at doses of 10, 55 or 300 mg/kg/day resulted in several changes in the fundic… Expand
  • 48
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Bovine Salpingo-oophoritis Produced with Semen Containing a Mycoplasma
A Mycoplasma, which was a natural pathogen for the bovine mammary gland was added to bull semen prior to processing and freezing in liquid nitrogen. Twelve virgin heifers were inseminated with frozen… Expand
  • 29
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BR96-Doxorubicin Conjugate (BMS-182248) Versus Doxorubicin: A Comparative Toxicity Assessment in Rats
The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m2… Expand
  • 29
  • 1
Pathology of feline toxoplasmosis.
— —A retrospective pathologic study of sixteen cats with toxoplasmosis revealed that the most consistent lesion was an interstitial pneumonia accompanied by fibrinous exudate, focal necrosis,… Expand
  • 13
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Single-dose and multiple-dose intravenous toxicity studies of BMY-25282 in rats.
Single-dose and multiple-dose (daily X 5 and weekly X 5) intravenous toxicity studies in rats were conducted to determine the possible acute and delayed toxicity of BMY-25282… Expand
  • 18
  • 1
Tallysomycin S10b: Experimental antitumor activity and toxicity
SummaryTallysomycin S10b (TLM S10b), a structural analog of bleomycin (BLM), was evaluated and compared with BLM for antitumor activity in several murine tumor systems and for toxic effects in mice… Expand
  • 9
  • 1
The toxicologic evaluation of marcellomycin--an antineoplastic anthracycline antibiotic.
Dose-related toxicologic effects of marcellomycin, an antineoplastic anthracycline antibiotic, were observed in single-dose studies in mice iv (43.05-67.65 mg/m2) and dogs iv (41.0-90.2 mg/m2), and… Expand
  • 2
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A murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice.
Meningitis and meningoencephalomyelitis caused by Listeria monocytogenes were experimentally established in mice. The pathological changes in brain and spinal cord resulting from the infection… Expand
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