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Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine
A spectrum of proliferative cutaneous lesions occurred in 12 dogs at the injection site of live canine oral papillomavirus (COP) vaccine, suggesting a viral etiology for the masses. Lesions includedExpand
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Lesions of Spontaneous Subclinical Disease in Beagle Dogs
Postmortem examination of 1000 commercially bred Beagle dogs used in 39 drug-safety evaluations showed a spectrum of concurrent lesions of spontaneous, subclinical disease that was used to develop aExpand
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Gastric Enterochromaffin-Like Cell Hyperplasia and Neoplasia in the Rat: An Indirect Effect of the Histamine H2-Receptor Antagonist, BL-6341
Oral administration of BL-6341 hydrochloride, a long-acting histamine H2-receptor antagonist, to rats for 2 years at doses of 10, 55 or 300 mg/kg/day resulted in several changes in the fundicExpand
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Bovine Salpingo-oophoritis Produced with Semen Containing a Mycoplasma
A Mycoplasma, which was a natural pathogen for the bovine mammary gland was added to bull semen prior to processing and freezing in liquid nitrogen. Twelve virgin heifers were inseminated with frozenExpand
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BR96-Doxorubicin Conjugate (BMS-182248) Versus Doxorubicin: A Comparative Toxicity Assessment in Rats
The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m2Expand
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Pathology of feline toxoplasmosis.
— —A retrospective pathologic study of sixteen cats with toxoplasmosis revealed that the most consistent lesion was an interstitial pneumonia accompanied by fibrinous exudate, focal necrosis,Expand
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Single-dose and multiple-dose intravenous toxicity studies of BMY-25282 in rats.
Single-dose and multiple-dose (daily X 5 and weekly X 5) intravenous toxicity studies in rats were conducted to determine the possible acute and delayed toxicity of BMY-25282Expand
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Tallysomycin S10b: Experimental antitumor activity and toxicity
SummaryTallysomycin S10b (TLM S10b), a structural analog of bleomycin (BLM), was evaluated and compared with BLM for antitumor activity in several murine tumor systems and for toxic effects in miceExpand
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The toxicologic evaluation of marcellomycin--an antineoplastic anthracycline antibiotic.
Dose-related toxicologic effects of marcellomycin, an antineoplastic anthracycline antibiotic, were observed in single-dose studies in mice iv (43.05-67.65 mg/m2) and dogs iv (41.0-90.2 mg/m2), andExpand
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A murine model for listerial meningitis and meningoencephalomyelitis: therapeutic evaluation of drugs in mice.
Meningitis and meningoencephalomyelitis caused by Listeria monocytogenes were experimentally established in mice. The pathological changes in brain and spinal cord resulting from the infectionExpand
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