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Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis
The genome sequence of the protist Trichomonas vaginalis predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins.
- R. Hirt, J. Logsdon, B. Healy, M. Dorey, W. Doolittle, T. Embley
- BiologyProceedings of the National Academy of Sciences…
- 19 January 1999
Phylogenetic analyses of RPB1 sequences strongly support the notion that Microsporidia are not early-diverging eukaryotes but instead are specifically related to Fungi, and reexamination of elongation factors EF-1alpha and EF-2 sequence data show support for an early (Archezoan) divergence of these amitochondriate protists to be weak and likely caused by artifacts in phylogenetic analyses.
The archaebacterial origin of eukaryotes
- C. Cox, P. Foster, R. Hirt, S. Harris, T. Embley
- BiologyProceedings of the National Academy of Sciences
- 23 December 2008
The analyses favor a topology that supports the eocyte hypothesis rather than archaebacterial monophyly and the 3-domains tree of life, which is thought to be central to understanding the evolution of the eukaryotic cell.
The genome of the protist parasite Entamoeba histolytica
The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen.
Some rumen ciliates have endosymbiotic methanogens.
- B. Finlay, G. Esteban, K. J. Clarke, A. Williams, T. Embley, R. Hirt
- Biology, MedicineFEMS microbiology letters
- 1 April 1994
Most of the small ciliate protozoa, including Dasytricha ruminantium and Entodinium spp. living in the rumen of sheep, were found to have intracellular bacteria. These bacteria were not present in…
Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I
Recruitment of complex I subunits into a H2-producing pathway provides evidence that mitochondria and hydrogenosomes are aerobic and anaerobic homologues of the same endosymbiotically derived organelle.
A mitochondrial remnant in the microsporidian Trachipleistophora hominis
It is shown that a highly specific antibody raised against a Trachipleistophora hominis Hsp70 protein detects the presence of numerous tiny organelles with double membranes in this human microsporidial parasite, providing further evidence of the reluctance of eukaryotes to lose the mitochondrial organelle, even when its canonical function of aerobic respiration has been apparently lost.
Early branching eukaryotes?
Trichomonas vaginalis surface proteins: a view from the genome.
A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi
- A. Tsaousis, Edmund R. S. Kunji, A. V. Goldberg, J. Lucocq, R. Hirt, T. Embley
- 22 May 2008
All four E. cuniculi transporters can transport ATP, and three of them are expressed on the surface of the parasite when it is living inside host cells, consistent with the traditional relationship between mitochondrion and host being subverted.