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Harnessing neuroplasticity for clinical applications
Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in theExpand
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Mild experimental brain injury in the rat induces cognitive deficits associated with regional neuronal loss in the hippocampus.
Memory dysfunction following mild human traumatic brain injury (TBI) is a common clinical observation, but the pathologic substrate underlying this loss of function has not been well-characterized.Expand
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Dose-response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats
Acute neuropathology following experimental traumatic brain injury results in the rapid necrosis of cortical tissue at the site of injury. This primary injury is exacerbated in the ensuing hours andExpand
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Therapy development for diffuse axonal injury.
Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI) and a major player in its subsequent morbidity. The importance of this widespread axonal damage has beenExpand
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Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury
The present study characterized whether inflammatory leukocytic infiltration is temporally and regionally correlated with neuronal degeneration and/or blood brain barrier (BBB) breakdown resultingExpand
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Synaptogenesis in the hippocampal CA1 field following traumatic brain injury.
Traumatic brain injury (TBI) results in both acute and chronic disruption of cognitive ability that may be mediated through a disruption of hippocampal circuitry. Experimental models of TBI haveExpand
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Stance phase stability and swing phase clearance, prerequisites for normal ambulation, often are lost in the gait of children with cerebral palsy. Lengthening of the hamstrings usually will improveExpand
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Combination therapies for traumatic brain injury: prospective considerations.
Traumatic brain injury (TBI) initiates a cascade of numerous pathophysiological events that evolve over time.Despite the complexity of TBI, research aimed at therapy development has almostExpand
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Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma.
Previous studies have suggested that the neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are neuroprotective or neurotrophic for certain subpopulations of hippocampalExpand
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Coping with Multicollinearity: An Example on Application of Principal Components Regression in Dendroecology
The theory and application of principal components regression, a method for coping with multicollinearity among independent variables in analyzing ecological data, is exhibited in detail. A concreteExpand
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