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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer’s disease in the combined dataset. Expand
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism. Expand
The Concreteness Effect: Evidence for Dual Coding and Context Availability
The term concreteness effect refers to the observation that concrete nouns are processed faster and more accurately than abstract nouns in a variety of cognitive tasks. Two models have been proposedExpand
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia.
The observed influence of the apolipoprotein E epsilon4 (APOE4) allele on CSF 24S-hydroxycholesterol concentrations with a gene-dosage effect suggests the existence of a link between the AD risk factor APOE4 and CNS cholesterol metabolism. Expand
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease. Expand
Subjective Memory Impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria
This study aims to identify previous and current definitions of SMI used in published research and to propose a set of criteria that may help increase SMI's predictive power of future cognitive decline. Expand
Schizophrenia and complications of pregnancy and labor: an individual patient data meta-analysis.
It is concluded that some abnormalities of pregnancy and delivery may be associated with development of schizophrenia and the pathophysiology may involve hypoxia and so future studies should focus on the accurate measurement of this exposure. Expand
A genetic variation of the inflammatory cytokine interleukin‐6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease
The results support an association of the C allele of the IL‐6 genotype with a delayed initial onset and reduced disease risk and indicate that genetically determined alterations of the immune response may modify the course of AD. Expand
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
The data confirm the results of a recently performed pilot study in an independent sample and suggest that the catD genotype is strongly associated with the risk for AD. Expand
Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding
It is suggested that in patients with MCI, an increase in MTL activation is necessary for successful memory encoding, which may reflect a compensatory response to the beginning of AD pathology. Expand