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Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study.
BACKGROUND Sleep-disordered breathing is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for sleep-disordered… Expand
The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study.
- H. Marti-Soler, C. Hirotsu, +9 authors R. Heinzer
- The Lancet. Respiratory medicine
- 1 September 2016
BACKGROUND Diagnosis of sleep-disordered breathing requires overnight recordings, such as polygraphy or polysomnography. Considering the cost and low availability of these procedures, preselection of… Expand
Prevalence and determinants of periodic limb movements in the general population
Periodic limb movements during sleep (PLMS) are sleep phenomena characterized by periodic episodes of repetitive stereotyped limb movements. The aim of this study was to describe the prevalence and… Expand
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 haplotype is common in the general… Expand
DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.
STUDY OBJECTIVE Prior research has identified five common genetic variants associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested… Expand
Prevalence of sleep apnoea syndrome in the middle to old age general population.
On the basis of a large populationbased sample who underwent full polysomnography at home (HypnoLaus cohort), we recently reported that 49·7% of men and 23·4% of women aged 40 years or older had an… Expand
Age and gender variations of sleep in subjects without sleep disorders
Objective. Although sleep is a biomarker for general health and pathological conditions, its changes across age and gender are poorly understood. Methods. Subjective evaluation of sleep was assessed… Expand
Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.
STUDY OBJECTIVES Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility… Expand
Obstructive Sleep Apnea Severity and Overnight Body Fluid Shift before and after Hemodialysis.
- A. Ogna, V. Forni Ogna, +8 authors R. Heinzer
- Clinical journal of the American Society of…
- 5 June 2015
BACKGROUND AND OBJECTIVES Obstructive sleep apnea is associated with significantly increased cardiovascular morbidity and mortality. Fluid overload may promote obstructive sleep apnea in patients… Expand