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- Publications
- Influence
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, Kotb Abdelmohsen, +2,464 authors S. Zughaier
- Biology, Medicine
- Autophagy
- 18 April 2012
In 2008 we published the first set of guidelines for
standardizing research in autophagy. Since then, research on
this topic has continued to accelerate, and many new scientists
have entered the… Expand
Complete genome sequence of the Q-fever pathogen Coxiella burnetii
- R. Seshadri, I. Paulsen, +21 authors J. Heidelberg
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 18 April 2003
The 1,995,275-bp genome of Coxiella burnetii, Nine Mile phase I RSA493, a highly virulent zoonotic pathogen and category B bioterrorism agent, was sequenced by the random shotgun method. This… Expand
Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis.
- R. Heinzen, M. Scidmore, D. Rockey, T. Hackstadt
- Biology, Medicine
- Infection and immunity
- 1 March 1996
Coxiella burnetii and Chlamydia trachomatis are bacterial obligate intracellular parasites that occupy distinct vacuolar niches within eucaryotic host cells. We have employed immunofluorescence,… Expand
Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane.
- T. Hackstadt, D. Rockey, R. Heinzen, M. Scidmore
- Biology, Medicine
- The EMBO journal
- 1 March 1996
Chlamydia trachomatis acquires C6‐NBD‐sphingomyelin endogenously synthesized from C6‐NBD‐ceramide and transported to the vesicle (inclusion) in which they multiply. Here we explore the mechanisms of… Expand
Temporal analysis of Coxiella burnetii morphological differentiation.
- S. A. Coleman, E. Fischer, D. Howe, D. Mead, R. Heinzen
- Biology, Medicine
- Journal of bacteriology
- 1 November 2004
Coxiella burnetii undergoes a poorly defined developmental cycle that generates morphologically distinct small-cell variants (SCV) and large-cell variants (LCV). We developed a model to study C.… Expand
Isolation from Animal Tissue and Genetic Transformation of Coxiella burnetii Are Facilitated by an Improved Axenic Growth Medium
- Anders Omsland, P. Beare, +5 authors R. Heinzen
- Biology, Medicine
- Applied and Environmental Microbiology
- 8 April 2011
ABSTRACT We recently described acidified citrate cysteine medium (ACCM), which supports host cell-free (axenic) growth of Coxiella burnetii. After 6 days of incubation, greater than 3 logs of growth… Expand
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
- Daniel E. Voth, R. Heinzen
- Biology, Medicine
- Cellular microbiology
- 1 April 2007
Most intracellular parasites employ sophisticated mechanisms to direct biogenesis of a vacuolar replicative niche that circumvents default maturation through the endolysosomal cascade. However, this… Expand
Comparative Genomics Reveal Extensive Transposon-Mediated Genomic Plasticity and Diversity among Potential Effector Proteins within the Genus Coxiella
- P. Beare, N. Unsworth, +9 authors R. Heinzen
- Biology, Medicine
- Infection and Immunity
- 1 December 2008
ABSTRACT Genetically distinct isolates of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in vitro infectivity/cytopathology and pathogenicity for… Expand
The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor
- J. H. Carlson, W. Whitmire, +9 authors H. Caldwell
- Biology, Medicine
- Infection and Immunity
- 17 March 2008
ABSTRACT Chlamydia trachomatis possesses a cryptic 7.5-kb plasmid of unknown function. Here, we describe a comprehensive molecular and biological characterization of the naturally occurring… Expand
Host cell-free growth of the Q fever bacterium Coxiella burnetii
- Anders Omsland, D. Cockrell, +5 authors R. Heinzen
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 March 2009
The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in… Expand
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