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Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development
TLDR
A single-cell transcriptome atlas encompassing embryonic, postnatal, and adult mouse mammary development is generated, mapping the chronology of transcriptionally and epigenetically distinct cell states and distinguish fetal mammary stem cells (fMaSCs) from their precursors and progeny. Expand
Multiple Molecular Subtypes of Triple-Negative Breast Cancer Critically Rely on Androgen Receptor and Respond to Enzalutamide In Vivo
TLDR
It is indicated that non-LAR subtypes of TNBC are AR dependent and, moreover, that enzalutamide is a promising targeted therapy for multiple molecular sub types of AR+ TNBC. Expand
Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial
TLDR
A 6-month intervention of mixed soy isoflavones in healthy, high-risk adult Western women did not reduce breast epithelial proliferation, suggesting a lack of efficacy for breast cancer prevention and a possible adverse effect in premenopausal women. Expand
Ethanol consumption modifies dendritic cell antigen presentation in mice.
TLDR
Ethanol alters CD11c+CD8(alpha)+ DC function, affecting cytokines responsible for adaptive immune responses, and a unifying hypothesis for the underlying mechanism(s) of ethanol's effect upon adaptive immune function is proposed. Expand
Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis
TLDR
The hypothesis that a synchronized decrease in miRNAs, such as miR-150, at late pregnancy serves to allow translation of targets crucial for lactation is supported. Expand
Patterns of Sex Steroid Hormones in Nipple Aspirate Fluid during the Menstrual Cycle and after Menopause in Relation to Serum Concentrations
TLDR
This is the first description of the temporal relationships of sex steroids in NAF and serum relative to the menstrual cycle and insights into the lack of correlation of Naf and breast tissue estrogens with serum estrogens are provided, and new hypotheses are generated. Expand
Hormonal Determinants of Nipple Aspirate Fluid Yield among Breast Cancer Cases and Screening Controls
TLDR
NAF-yielders show higher prolactin than non-y yielders, regardless of menopause and parity; implications of this and other endocrine differences on NAF biomarkers of breast cancer risk deserve further study. Expand
Methodological considerations in estrogen assays of breast fluid and breast tissue
TLDR
The similarity of levels between breasts and between ducts suggests that estimates of estrogen exposure does not require multiple samples, however, unavailability of fluid may require rFNA in some cases. Expand
Nipple Aspirate Fluid Hormone Concentrations and Breast Cancer Risk
TLDR
The significantly higher concentration of DHEA in NAF of cases and its correlation with NAF estradiol indicates a potentially important role of this steroid in breast cancer risk; however, the negative association of progesterone with risk is tentative. Expand
P3-04-03: Identification of Hormone-Responsive Genes as Biomarkers for Menstrual Cycle Phases and Menopausal Status.
TLDR
The results indicate that the menstrual cycle phases and menopausal status determined by age, patient survey and serum hormone concentrations are reflected in the expression of specific gene sets in the normal breast. Expand
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