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Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
TLDR
The data demonstrate that Nkx2-5 is essential for normal heart morphogenesis, myogenesis, and function, and this gene is a component of a genetic pathway required for myogenic specialization of the ventricles.
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
TLDR
A specialized role for CxCR7 in endothelial biology and valve development is revealed and the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CX CR4 is highlighted.
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
TLDR
The expression data implicate Nkx-2.5 in commitment to and/or differentiation of the myocardial lineage and demonstrate that cardiogenic progenitors can be distinguished at a molecular level by late gastrulation.
Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.
TLDR
The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism.
Chamber formation and morphogenesis in the developing mammalian heart.
TLDR
The spatial pattern of expression of genes encoding atrial natriuretic factor, sarcoplasmic reticulum calcium ATPase, Chisel,Irx5, Irx4, myosin light chain 2v, and beta-myosin heavy chain are traced and a two-step model for chamber formation in the embryonic heart is proposed.
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
TLDR
CARP is a YB-1 associated factor and represents the first identified cardiac-restricted downstream regulatory gene in the homeobox gene Nkx2-5 pathway and may serve as a negative regulator of HF-1-dependent pathways for ventricular muscle gene expression.
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
TLDR
The results implicate scl as a crucial regulator of early hematopoiesis and Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos.
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