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Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation
Context Thirteen new randomized, controlled trials are available since a 1999 meta-analysis of antithrombotic agents for stroke prevention in patients with atrial fibrillation. Contribution This… Expand
Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications.
- W. Feinberg, J. Blackshear, A. Laupacis, R. Kronmal, R. Hart
- Archives of internal medicine
- 13 March 1995
The prevalence of atrial fibrillation (AF) is related to age. Anticoagulation is highly effective in preventing stroke in patients with AF, but the risk of hemorrhage may be increased in older… Expand
Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Background and Purpose— This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of… Expand
Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation
Adjusted-dose warfarin and aspirin reduce stroke in patients with atrial fibrillation, and warfarin is substantially more efficacious than aspirin. The benefit of antithrombotic therapy was not off...
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
- J. Eikelboom, S. Connolly, +46 authors S. Yusuf
- The New England journal of medicine
- 27 August 2017
BACKGROUND We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS In this double‐blind… Expand
Embolic strokes of undetermined source: the case for a new clinical construct
- R. Hart, H. Diener, S. Coutts, J. Easton, for the Cryptogenic StrokeESUS International Working Group
- The Lancet Neurology
- 1 April 2014
Cryptogenic (of unknown cause) ischaemic strokes are now thought to comprise about 25% of all ischaemic strokes. Advances in imaging techniques and improved understanding of stroke pathophysiology… Expand
Effect of clopidogrel added to aspirin in patients with atrial fibrillation.
BACKGROUND Vitamin K antagonists reduce the risk of stroke in patients with atrial fibrillation but are considered unsuitable in many patients, who usually receive aspirin instead. We investigated… Expand
Selecting Patients With Atrial Fibrillation for Anticoagulation: Stroke Risk Stratification in Patients Taking Aspirin
Background—The rate of stroke in atrial fibrillation (AF) depends on the presence of comorbid conditions and the use of antithrombotic therapy. Although adjusted-dose warfarin is superior to aspirin… Expand
Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy. Stroke Prevention in Atrial Fibrillation Investigators.
- R. Hart, L. Pearce, R. Rothbart, J. McA'Nulty, R. Asinger, J. Halperin
- Journal of the American College of Cardiology
OBJECTIVE This study was performed to characterize the risk of stroke in elderly patients with recurrent intermittent atrial fibrillation (AF). BACKGROUND Although intermittent AF is common,… Expand
Dissections of cervical and cerebral arteries.
Dissections have been reported with increasing frequency in recent years. The authors discuss dissection of extracranial carotid, intracranial cerebral, and vertebrobasilar arteries and consider… Expand