Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Observations support the idea that anaesthetics exert a specific effect on these ion-channel proteins, and allow for the future testing of specific hypotheses of the action of anaesthetic action.
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
- M. Bowker-Kinley, W. Davis, P. Wu, R. Harris, K. M. Popov
- Biology, Computer ScienceBiochemical Journal
Results provide the first evidence that the unique tissue distribution and kinetic characteristics of the isoenzymes of PDK are among the major factors responsible for tissue-specific regulation of the pyruvate dehydrogenase complex activity.
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.
- M. Mulligan, I. Ponomarev, S. Bergeson
- Biology, MedicineProceedings of the National Academy of Sciences…
- 18 April 2006
This study demonstrates the use of a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and a congenic strain for identification of cis regulation and several functional groups were found to be significantly overrepresented.
Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics
- R. Mayfield, J. Lewohl, P. Dodd, A. Herlihy, Jianwen Liu, R. Harris
- Medicine, BiologyJournal of Neurochemistry
- 1 May 2002
Examination of expression patterns in frontal and motor cortices of three groups of chronic alcoholic and matched control cases suggests that multiple pathways may be important for neuropathology and altered neuronal function observed in alcoholism.
Gene expression in human alcoholism: microarray analysis of frontal cortex.
- J. Lewohl, L. Wang, M. Miles, L. Zhang, P. Dodd, R. Harris
- MedicineAlcoholism: Clinical and Experimental Research
- 1 December 2000
These gene expression changes suggest a mechanism for the loss of cerebral white matter in alcoholics as well as alterations that may lead to the neurotoxic actions of ethanol.
The Anesthetic Mechanism of Urethane: The Effects on Neurotransmitter-Gated Ion Channels
At concentrations close to anesthetic 50% effective concentration, urethane had modest effects on all channels tested, suggesting the lack of a single predominant target for its action, which may account for its usefulness as a veterinary anesthetic.
Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence
- I. Ponomarev, Shi Wang, Lingling Zhang, R. Harris, R. Mayfield
- Medicine, BiologyJournal of Neuroscience
- 1 February 2012
A novel systems approach to transcriptome profiling in postmortem human brains generated a systemic view of brain alterations associated with alcohol abuse and identified critical cellular components and previously unrecognized epigenetic determinants of gene coexpression relationships and discovered novel markers of chromatin modifications in alcoholic brain.
Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals
A consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals is revealed.
A molecular model of human branched-chain amino acid metabolism.
- A. Suryawan, J. Hawes, R. Harris, Y. Shimomura, A. Jenkins, S. Hutson
- BiologyAmerican Journal of Clinical Nutrition
- 1 July 1998
In primates the high ratio of transaminase to oxidative capacity in the entire gastrointestinal tract serves to prevent loss of essential BCAA carbon and raises the possibility that the gastrointestinal tract contributes to the plasma branched-chain alpha-keto acid pool.
Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics
The results suggest that the α subunits of strychnine‐sensitive glycine receptors contain sites of action for n‐alcohols, propofol, alphaxalone, pentobarbitone and volatile anaesthetics, but not for ketamine and etomidate.