• Publications
  • Influence
Cerebral Vasomotion: A 0.1-Hz Oscillation in Reflected Light Imaging of Neural Activity
A major source of variability in the captured light signal is a pervasive low-frequency (0.1-Hz) oscillation which apparently results from regional cerebral blood flow which is present in brain parenchyma as well as the microvasculature. Expand
Brain morphology associated with obstructive sleep apnea.
Diminished regional and often unilateral gray matter loss was apparent in multiple sites of the brain in patients with OSA, including the frontal and parietal cortex, temporal lobe, anterior cingulate, hippocampus, and cerebellum, which suggests onset of neural deficits early in the OSA syndrome. Expand
Dorsal raphe neurons: depression of firing during sleep in cats
The results of lesion and pharmacological experiments suggest that 5-HT-containing neurons localized in the raphe nuclei of the brain stem participate functionally in the control of slow wave sleepExpand
A method for removal of global effects from fMRI time series
LMGS removes all effects correlated with the global signal, and may be especially useful for fMRI data that include large global effects and for generating detrended images to use with subsequent volume-of-interest (VOI) analyses. Expand
Brain structural changes in obstructive sleep apnea.
White matter is extensively affected in OSA patients; the alterations include axons linking major structures within the limbic system, pons, frontal, temporal and parietal cortices, and projections to and from the cerebellum. Expand
The human tongue during sleep: Electromyographic activity of the genioglossus muscle
Electromyographic studies of the genioglossus muscle during sleep were conducted in six healthy human volunteers and results are discussed in context with problems encountered in hypersomniac patients with the sleep apnea syndrome. Expand
Sudden Infant Death Syndrome: A Failure of Compensatory Cerebellar Mechanisms?
  • R. Harper
  • Medicine
  • Pediatric Research
  • 1 August 2000
Physiologic characteristics of infants who later succumb to SIDS, and cardiovascular events associated with the fatal scenario suggest a failure of interaction between somatomotor and autonomic control mechanisms in infants at risk for the syndrome. Expand
Regional Brain Gray Matter Loss in Heart Failure.
Heart failure patients showed significant and largely lateralized gray matter loss in autonomic and respiratory-related areas as well as regions not classically associated with such control, which may contribute to inappropriate cognitive, autonomic, and breathing regulation in HF. Expand
Dynamic Analysis of Cardiac R-R Intervals in Normal Infants and in Infants Who Subsequently Succumbed to the Sudden Infant Death Syndrome
The differences in cardiac rate dynamics suggest altered autonomic control in infants who succumb to SIDS, and it is speculated that the autonomic disturbance may lead to cardiac instability or may indicate CNS alterations with the potential to affect other vital functions. Expand
Relationship between Obstructive Sleep Apnea Severity and Sleep, Depression and Anxiety Symptoms in Newly-Diagnosed Patients
A strong link between OSA severity and psychological symptoms did not appear in these newly diagnosed patients, suggesting that mechanisms additional to the number and frequency of hypoxic events and arousals occurring with apneas contribute to adverse health effects in OSA. Expand