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Early development of Xenopus laevis : a laboratory manual
This book discusses the development of Xenopus laevis Embryos and Temperature Dependence, and the role of radiolysis in this development. Expand
In situ hybridization: an improved whole-mount method for Xenopus embryos.
- R. Harland
- Biology, Medicine
- Methods in cell biology
Dishevelled controls cell polarity during Xenopus gastrulation
- J. Wallingford, B. Rowning, K. Vogeli, U. Rothbächer, S. Fraser, R. Harland
- Biology, Medicine
- 4 May 2000
It is shown that polarized cell behaviour is essential for convergent extension and is controlled by vertebrate Dishevelled, suggesting that a vertebrate equivalent of the Drosophila planar cell polarity signalling cascade may be required for normal gastrulation. Expand
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
- J. McMahon, S. Takada, L. Zimmerman, C. Fan, R. Harland, A. McMahon
- Medicine, Biology
- Genes & development
- 15 May 1998
It is demonstrated that inhibition of BMP signaling by axially secreted Noggin is an important requirement for normal patterning of the vertebrate neural tube and somite. Expand
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
The activity of exogenous noggin RNA in embryonic axis induction and the localized expression of endogenous noggan transcripts suggest that noggins plays a role in normal dorsal development. Expand
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
It is reported that noggin protein binds BMP4 with high affinity and can abolish B MP4 activity by blocking binding to cognate cell-surface receptors and these data suggest that nogsgin secreted by the organizer patterns the embryo by interrupting BMP signaling. Expand
Formation and function of Spemann's organizer.
The organizer is formed in an equatorial sector of the blastula stage amphibian embryo by cells that have responded to two maternal agents: a general mesoendoderm inducer and a dorsal modifier (probably involving the Wnt signaling pathway). Expand
Neural induction by the secreted polypeptide noggin.
Noggin has the expression pattern and activity expected of an endogenous neural inducer and acts at the appropriate stage to be an endogenous Neural inducing signal in Xenopus. Expand
Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.
WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction, which is required for neural crest formation and display overlapping but nonidentical activities. Expand
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.
Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues. Expand