R. Hardeland

Publications300
h-index60
Citations12,922
Highly Influential Citations429
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Melatonin: Nature's most versatile biological signal?
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans,… Expand
  • 729
  • 33
Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance.
Melatonin has been shown to protect against oxidative stress in various, highly divergent experimental systems. There are many reasons for its remarkable protective potential. Signaling effects… Expand
  • 584
  • 22
Melatonin—A pleiotropic, orchestrating regulator molecule
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system… Expand
  • 540
  • 22
Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines.
Kynuramines represent their own class of biogenic amines. They are formed either by decarboxylation of kynurenines or pyrrole ring cleavage of indoleamines. N(2)-formylated compounds formed in this… Expand
  • 398
  • 14
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms
Endogenous circadian and exogenously driven daily rhythms of antioxidative enzyme activities and of low molecular weight antioxidants (LMWAs) are described in various phylogenetically distant… Expand
  • 296
  • 12
Melatonin: Signaling mechanisms of a pleiotropic agent
Melatonin acts both as a hormone of the pineal gland and as a local regulator molecule in various tissues. Quantities of total tissue melatonin exceed those released from the pineal. With regard to… Expand
  • 176
  • 12
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
Inflammation is a complex phenomenon involving multiple cellular and molecular interactions which must be tightly regulated. Cyclooxygenase-2 (COX) is the key enzyme that catalyzes the two sequential… Expand
  • 269
  • 10
Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites
  • R. Hardeland
  • Medicine, Biology
  • Cellular and Molecular Life Sciences
  • 17 March 2008
Abstract.In its role as a pineal hormone, melatonin is a pleiotropic, nocturnally peaking and systemically acting chronobiotic. These effects are largely explained by actions via G protein-coupled… Expand
  • 198
  • 10
Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus).
The antioxidant melatonin was recently identified in a variety of edible plants and seeds in high concentrations. In plants, as in animals, melatonin is believed to function as a free radical… Expand
  • 194
  • 10
The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed… Expand
  • 331
  • 9