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Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies.
TLDR
Simple indices of insulin sensitivity and secretion may be reasonable surrogates for more sophisticated measures in epidemiologic studies, particularly after control for insulin sensitivity index.
An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.
TLDR
A genomic scan was conducted to identify loci linked to diabetes and body-mass index in Pima Indians, a Native American population with a high prevalence of type II diabetes.
Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes
TLDR
It is suggested that determination of glycated haemoglobin or fasting plasma glucose concentrations alone may be acceptable alternatives to measuring glucose concentration two hours after challenge with 75 g glucose for the diagnosis of diabetes.
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population.
TLDR
Highly suggestive evidence for linkage emerged for two genomic regions using two- and multipoint sib-pair regression methods; both regions harbored neurogenetic candidate genes.
Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease
TLDR
In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis.
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.
TLDR
The risk of diabetes was significantly higher in siblings born after the mother developed diabetes than in those born before the mother's diagnosis of diabetes, and there were no significant differences in risk of Diabetes or BMI between offspring born before and after the father was diagnosed with diabetes.
The transcriptional landscape of age in human peripheral blood
TLDR
Differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index and the transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models.
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
TLDR
Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreases rates of glucose oxidation.
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