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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
The aim of broth and agar dilution methods is to determine the lowest concentration of the assayed antimicrobial agent (minimal inhibitory concentration, MIC) that, under defined test conditions,…
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
Peptide Antimicrobial Agents
The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.
Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes
The latest release implements an ability to view sequence polymorphisms in P. aeruginosa PAO1 versus other reference strains, incomplete genomes and single gene sequences, which aids analysis of phenotypic variation between closely related isolates and strains, as well as wider population genomics and evolutionary studies.
InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation
The recent integration of bovine data makes InnateDB the first integrated network analysis platform for this agriculturally important model organism, and a range of improvements to the integrated bioinformatics solutions are reported.
NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data
This protocol provides a step-wise description of how to effectively use NetworkAnalyst to perform network analysis and visualization from gene lists; to perform meta- analysis on gene expression data while taking into account multiple metadata parameters; and, finally, to perform a meta-analysis of multiple gene expressionData sets.
Cationic peptides: effectors in innate immunity and novel antimicrobials.
- R. Hancock
- BiologyThe Lancet. Infectious diseases
- 1 October 2001
The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1
- M. G. Scott, D. Davidson, M. Gold, D. Bowdish, R. Hancock
- BiologyThe Journal of Immunology
- 1 October 2002
It is demonstrated that LL-37 is a potent antisepsis agent with the ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabinomannan and protects mice against lethal endotoxemia.