• Publications
  • Influence
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
BACKGROUND In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phospholipase C zeta (PLCzeta). However, it still remains to be conclusively shown thatExpand
  • 211
  • 17
Analysis of a deep transcriptome from the mantle tissue of Patella vulgata Linnaeus (Mollusca: Gastropoda: Patellidae) reveals candidate biomineralising genes
The gastropod Patella vulgata is abundant on rocky shores in Northern Europe and a significant grazer of intertidal algae. Here we report the application of Illumina sequencing to develop aExpand
  • 50
  • 3
  • PDF
Cytochrome c biogenesis System I
Cytochromes c are widespread respiratory proteins characterized by the covalent attachment of heme. The formation of c‐type cytochromes requires, in all but a few exceptional cases, the formation ofExpand
  • 60
  • 2
i‐Patch: Interprotein contact prediction using local network information
Biological processes are commonly controlled by precise protein‐protein interactions. These connections rely on specific amino acids at the binding interfaces. Here we predict the binding residues ofExpand
  • 27
  • 2
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
BACKGROUND Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of maleExpand
  • 91
  • 1
Deciphering chemotaxis pathways using cross species comparisons
TLDR
We analysed 206 species encoding at least 1 homologue of each of the 5 core chemotaxis proteins (CheA, CheB, CheR, CheW and CheY). Expand
  • 72
  • 1
Honing the in silico toolkit for detecting protein disorder.
Not all proteins form well defined three-dimensional structures in their native states. Some amino-acid sequences appear to strongly favour the disordered state, whereas some can apparentlyExpand
  • 31
  • 1
  • PDF
Title Deciphering chemotaxis pathways using cross species comparisons Permalink
Background: Chemotaxis is the process by which motile bacteria sense their chemical environment and move towards more favourable conditions. Escherichia coli utilises a single sensory pathway, butExpand
  • 1
  • 1
SPINE bioinformatics and data‐management aspects of high‐throughput structural biology
TLDR
This article gives an overview of ongoing activity in the bioinformatics workpackage.SPINE (Structural Proteomics In Europe) was established in 2002 as an integrated research project to develop new methods and technologies for high‐throughput structural biology. Expand
  • 20
  • PDF
...
1
2
...