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Fringe is a glycosyltransferase that modifies Notch
Notch receptors function in highly conserved intercellular signalling pathways that direct cell-fate decisions, proliferation and apoptosis in metazoans. Fringe proteins can positively and negativelyExpand
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Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules*
Notch is a large cell-surface receptor known to be an essential player in a wide variety of developmental cascades. Here we show that Notch1 endogenously expressed in Chinese hamster ovary cells isExpand
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Dual Roles of Cripto as a Ligand and Coreceptor in the Nodal Signaling Pathway
ABSTRACT The EGF-CFC gene Cripto encodes an extracellular protein that has been implicated in the signaling pathway for the transforming growth factor beta (TGFβ) ligand Nodal. Although recentExpand
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Modulation of O-LinkedN-Acetylglucosamine Levels on Nuclear and Cytoplasmic Proteins in Vivo Using the PeptideO-GlcNAc-β-N-acetylglucosaminidase
O-LinkedN-acetylglucosamine (O-GlcNAc) is a ubiquitous and abundant post-translational modification found on nuclear and cytoplasmic proteins and is thought to be a dynamically regulated modificationExpand
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Role of glycosylation in development.
Researchers have long predicted that complex carbohydrates on cell surfaces would play important roles in developmental processes because of the observation that specific carbohydrate structuresExpand
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Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase.
Using a combination of conventional and affinity chromatographic techniques, we have purified a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase (O-GlcNAcExpand
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Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains
The atypical cadherin Fat acts as a receptor for a signaling pathway that regulates growth, gene expression, and planar cell polarity. Genetic studies in Drosophila identified the four-jointed geneExpand
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Nuclear pore complex glycoproteins contain cytoplasmically disposed O- linked N-acetylglucosamine
A novel form of protein-saccharide linkage consisting of single N- acetylglucosamine (GlcNAc) residues attached in O-linkages directly to the polypeptide backbone has been described (Holt, G. D., andExpand
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Notch Ligands Are Substrates for ProteinO-Fucosyltransferase-1 and Fringe*
O-Fucose has been identified on epidermal growth factor-like (EGF) repeats of Notch, and elongation of O-fucose has been implicated in the modulation of Notch signaling by Fringe. O-FucoseExpand
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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Forces on Notch receptors can modulate receptor signaling. Tugging on Notch receptor tunes signaling Notch proteins are transmembrane receptors that are important in the regulation of cell fate. TheyExpand
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