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Prevention of Autoimmunity by Targeting a Distinct, Noninvariant CD1d-reactive T Cell Population Reactive to Sulfatide
Class I and class II MHC-restricted T cells specific for proteins present in myelin have been shown to be involved in autoimmunity in the central nervous system (CNS). It is not yet known whetherExpand
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Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity
Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells. Cis-tetracosenoyl sulfatide is one of the immunodominant species in myelin asExpand
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Cross-Regulation between Type I and Type II NKT Cells in Regulating Tumor Immunity: A New Immunoregulatory Axis1
Negative immunoregulation is a major barrier to successful cancer immunotherapy. The NKT cell is known to be one such regulator. In this study we explored the roles of and interaction between theExpand
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PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells1
Invariant NKT (iNKT) cells recognize glycolipid Ags, such as the marine sponge-derived glycosphingolipid α-galactosylceramide (αGalCer) presented by the CD1d protein. In vivo activation of iNKT cellsExpand
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Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease.
Because of the paucity of known self lipid-reactive ligands for NKT cells, interactions among distinct NKT cell subsets as well as immune consequences following recognition of self glycolipids haveExpand
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Cross‐regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens
Natural killer T (NKT) cells generally recognize lipid‐antigens presented in the context of the MHC class I‐like molecule CD1d. CD1d‐restricted NKT cells consist of two broad subsets: Type I, whichExpand
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Mechanisms Involved in Enteropathy Induced by Administration of Nonsteroidal Antiinflammatory Drugs (NSAIDS)
Mice received oral indomethacin (1 mg/mouse) daily for five days. It was found that severe gastroenteropathy (ie, paralytic stomach and necrotic intestine) was induced on the sixth day. UlcerExpand
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Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination
Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on theExpand
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Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a β-linked self-glycolipid
TCR-mediated recognition of β-linked self-glycolipids bound to CD1d is poorly understood. Here, we have characterized the TCR repertoire of a CD1d-restricted type II NKT cell subset reactive toExpand
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Tissue‐specific expansion of NKT and CD5+B cells at the onset of autoimmune disease in (NZB×NZW)F1 mice
Natural killer T (NKT) cells and CD5+B cells were searched for in various immune organs of autoimmune prone (NZB×NZW)F1 (NZB/W F1) mice. The number of lymphocytes increased in the liver, spleen, andExpand
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