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The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.
Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptakeExpand
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A review of the metabolism and pharmacokinetics of paroxetine in man
Paroxetine is well absorbed from the gastrointestinal tract, and appears to undergo first‐pass metabolism which is partially saturable. Consistent with its lipophilic amine character, paroxetine isExpand
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Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites
Radiotracer studies have been carried out in animals and man using paroxetine labelled with carbon-14 either at the methylenedioxy-carbon atom or in the piperidine ring. Major metabolites wereExpand
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Metabolism of nabumetone (BRL 14777) by various species including man.
Radiotracer methodology was used to study the metabolic fate of 4-(6-methoxy-2-naphthyl)-butan-2-one (nabumetone) after oral administration to rats, mice, rabbits, dogs, rhesus monkeys and healthyExpand
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Sibutramine pharmacokinetics in young and elderly healthy subjects
AbstractObjective: To investigate the pharmacokinetics of the pharmacologically active metabolites of sibutramine (metabolites 1 and 2) in healthy young and elderly volunteers following a single oralExpand
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The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes.
Paroxetine is a selective serotonin reuptake inhibitor possessing anti-depressant activity. Demethylenation of the methylenedioxy phenyl group is the initial step in its metabolism, the liberatedExpand
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Configurational analysis of rhynchophylline-type oxindole alkaloids. The absolute configuration of ciliaphylline, rhynchociline, specionoxeine, isospecionoxeine, rotundifoline and isorotundifoline.
Abstract From a general configurational and conformational analysis of rhynchophyllinoid alkaloids, unique physical criteria are developed that differentiate between the 8 possible configurationalExpand
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Biotransformation of phenprocoumon in the rat.
The metabolic fate of phenprocoumon [3-(alpha-ethylbenzyl)-4-hydroxycoumarin] in the rat is described. The major metabolites, 4',-6-,7-, and 8-hyproxyphenprocoumon, have been identified yb massExpand
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Some new mitragyna-type indoles and oxindoles; the influence of stereochemistry on mass spectra.
Abstract The indole alkaloids corynantheidine and paynantheine have been epimerized to two new compounds and corynantheidine and mitragynine have been transformed to the corresponding oxindoles. TheExpand
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