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Comparison of Sphingosine 1-Phosphate–Induced Intracellular Signaling Pathways in Vascular Smooth Muscles: Differential Role in Vasoconstriction
The ability of S1P to act as a vasoactive mediator is dependent on the activation of associated signaling pathways and may vary in different VSM, and differential signaling may be related to the expression of S 1P receptor subtypes.
Calcium channel currents and their inhibition by (‐)‐baclofen in rat sensory neurones: modulation by guanine nucleotides.
It is concluded that calcium channels in d.r.g.s are associated with a nucleotide binding protein, and that this mediates the effect of baclofen and 2‐CA on calcium‐channel currents.
Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception
Gabapentin inhibits high‐threshold calcium channel currents in cultured rat dorsal root ganglion neurones
- K. Sutton, D. Martin, R. Pinnock, K. Lee, R. H. Scott
- BiologyBritish journal of pharmacology
- 1 January 2002
The present study is the first to demonstrate that gabapentin directly mediates inhibition of voltage‐gated Ca2+ influx in DRG neurones, providing a potential means for gABapentin to effectively mediate spinal anti‐nociception.
TNF-α receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones
Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression
Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells
Calcium‐dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analogue.
It is concluded that in cultured rat dorsal root ganglion neurones 2‐CA reduces ICa activation by a direct effect on an A1 adenosine receptor.
Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose.
The results indicate that both SF and cADPR release intracellular Ca2+ pools in DRG neurones and that they appear to act on subtly distinct stores or distinct intrACEllular Ca 2+ release mechanisms, possibly by modulating CICR.
A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats
- D. McClelland, R. Evans, Louise Barkworth, Duncan J. Martin, R. H. Scott
- BiologyBMC pharmacology
- 4 August 2004
Pregabalin reduces excitatory properties of cultured DRG neurones by modulating voltage-activated Ca2+ and K+ channels and its pharmacological activity is similar but not identical to that of gabapentin.