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Mersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.
Mersacidin (1) is a new peptide antibiotic containing beta-methyllanthionine. It is classified as a member of the proposed lantibiotic group of antibiotics, and is produced by a species of Bacillus.…
Stimulation of adenylate cyclase by water-soluble analogues of forskolin.
- A. Laurenza, Y. Khandelwal, N. J. De Souza, R. H. Rupp, H. Metzger, K. Seamon
- Biology, ChemistryMolecular pharmacology
- 1 July 1987
Water-soluble derivatives of forskolin may be useful for increasing cyclic AMP in broken cell preparations or in intact cell preparations where the presence of organic solvents, which are necessary to solubilize forskol, are detrimental.
An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum : isolation, structure and total synthesis
New prostacyclin analogues.
NEW PROSTACYCLIN ANALOGS
Cardiovascular effects of new water-soluble derivatives of forskolin.
- Y. Khandelwal, K. Rajeshwari, R. H. Rupp
- Chemistry, BiologyJournal of medicinal chemistry
- 1 October 1988
A series of 6- and 7-aminoacyl derivatives of 7-deacetylforskolin was prepared to provide water-soluble derivatives of the potent cardioactive diterpenoid forskolin that were evaluated for positive inotropic and blood pressure lowering properties in pharmacological models and selected as a candidate for clinical development.
Swalpamycin, a new macrolide antibiotic. II. Structure elucidation.
A new antibiotic swalpamycin (1) has been isolated from the culture broth of Streptomyces sp. Y-84,30967. The antibiotic has the molecular formula of C37H56O14 and belongs to the class of 16-membered…
Aluminum Chloride as a Powerful Catalyst for the Preparation of O-Isopropylidene and O-Benzylidene Derivatives of Labdanes
Preparation de composes diversement proteges a partir de l'epoxy-8,13 pentahydroxy-1α,3β,6β,7β,9α labdene-14 one-11
Synthesis of (±)-Praeruptorin A and Related Khellactone Derivatives
Aranorosin, a novel antibiotic from Pseudoarachniotus roseus. II. Structure elucidation.
Aranorosin, a new antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn and contains a novel 1-oxaspiro[4,5]decane ring system.