• Publications
  • Influence
Purification, Partial Characterization, and Cloning of Nitric Oxide-carrying Heme Proteins (Nitrophorins) from Salivary Glands of the Blood-sucking Insect Rhodnius prolixus(*)
Four nitric oxide (NO)-carrying proteins have been isolated from salivary glands of the blood-sucking insect Rhodnius prolixus. These have been given the collective name “nitrophorins,” andExpand
  • 150
  • 6
Nitric oxide loading of the salivary nitric-oxide-carrying hemoproteins (nitrophorins) in the blood-sucking bug Rhodnius prolixus.
The salivary glands of the blood-sucking bug Rhodnius prolixus are formed by a single layer of binucleated epithelial cells surrounded by a double layer of transversely oriented smooth muscle cells.Expand
  • 49
  • 3
Differential modulation of murine host immune response by salivary gland extracts from the mosquitoes Aedes aegypti and Culex quinquefasciatus.
Mosquitoes (Diptera: Culicidae) are major vectors of numerous infectious agents. Compounds in mosquito saliva not only facilitate blood-feeding, but may also have an impact upon the immune system ofExpand
  • 63
  • 3
Nitric oxide synthase activity from a hematophagous insect salivary gland
The salivary glands of the hematophagous insect, Rhodnius prolixus, contain a nitrosylhemeprotein that dissociates its ligand, NO, to the host tissues while the insect is searching for a blood meal.Expand
  • 69
  • 2
A Heme-binding Protein from Hemolymph and Oocytes of the Blood-sucking Insect, Rhodnius prolixus
A heme-binding protein has been isolated and characterized from both the hemolymph and oocytes of the blood-sucking insect, Rhodnius prolixus. The protein from both sources is identical in mostExpand
  • 81
  • 2
Reversible binding of nitric oxide by a salivary heme protein from a bloodsucking insect.
The bloodsucking bug Rhodnius prolixus has a salivary vasodilator, previously characterized as a nitrovasodilator, with salivary smooth muscle-relaxing and antiplatelet activity. Rhodnius salivaryExpand
  • 246
  • 1
The JAK kinase inhibitor CP‐690,550 supresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation
The somatic activating janus kinase 2 mutation (JAK2)V617F is detectable in most patients with polycythemia vera (PV). Here we report that CP‐690,550 exerts greater antiproliferative andExpand
  • 66
  • 1
Identification of yolk platelet-associated hydrolases in the oocytes of Rhodnius prolixus.
The yolk platelets from Rhodnius prolixus, a blood-sucking bug, are composed mostly of vitellin and here are shown to contain at least two hydrolytic enzymes, a phosphatase and a cathepsin D-likeExpand
  • 32
  • 1
Lipid transfer from insect fat body to lipophorin: comparison between a mosquito triacylglycerol-rich lipophorin and a sphinx moth diacylglycerol-rich lipophorin.
Two insect lipoproteins, triacylglycerol-rich Aedes aegypti lipophorin and diacylglycerol-rich Manduca sexta lipophorin, were compared in their ability to load neutral lipid from fat body. When fatExpand
  • 16
  • 1
Salivary vasodilators of Aedes triseriatus and Anopheles gambiae (Diptera: Culicidae).
Salivary vasodilators of Aedes aegypti (L.) and Anopheles albimanus (Wiedemann) were characterized previously as a tachykinin peptide and a catechol oxidase/peroxidase activity, respectively. ToExpand
  • 46