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Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans
Isogenic mutant strains of V. cholerae O1 lacking elements of a genetic regulon controlled by toxR and implicated in virulence were tested in volunteers. A deletion mutation in ctxA, the geneExpand
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Significance of toxin-coregulated pili as protective antigens of Vibrio cholerae in the infant mouse model.
The infant mouse cholera model has been used to evaluate the relative importance of toxin-coregulated pili (TCP) as protective antigens of Vibrio cholerae 01. Electron microscopic and immunoblottingExpand
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A search for cholera toxin (CT), toxin coregulated pilus (TCP), the regulatory element ToxR and other virulence factors in non-01/non-0139 Vibrio cholerae.
Twenty-four selected non-O1/non-O139 Vibrio cholerae strains were examined for the presence of virulence associated genes like ctxA, tcpA, toxR and the repetitive sequence (RS element). Seventeen ofExpand
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A major effort of biological scientists centers on exploration of phenomena of growth and development at the molecular level. A model for mechanisms of con­ trol at the cellular level has beenExpand
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Purification and analysis of colonization factor antigen I, coli surface antigen 1, and coli surface antigen 3 fimbriae from enterotoxigenic Escherichia coli.
Enterotoxigenic Escherichia coli fimbriae are immunogenic and play a key role in intestinal colonization. Native colonization factor antigen I, coli surface antigen 1, and coli surface antigen 3Expand
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Vibrio cholerae HlyA hemolysin is processed by proteolysis.
The leukocidal activity of the Vibrio cholerae hemolysin (HlyA) was utilized to detect, enrich, and clone hybridoma cells expressing neutralizing monoclonal antibody in a new survivor selectionExpand
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Morphological studies on fimbriae expressed by Vibrio cholerae 01.
Colonization of the small intestine is an essential step in the pathogenesis of Vibrio cholerae diarrhea. At least one type of fimbriae, known as TcpA are required for the colonization process. ThisExpand
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Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera.
A functional tcpA gene, encoding the major subunit of toxin-coregulated pili (TCP), is necessary for Vibrio cholerae O1 Ogawa strain 395 to colonize the human intestine and confer protective immunityExpand
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Vibrio cholerae non-O1 serogroup associated with cholera gravis genetically and physiologically resembles O1 E1 Tor cholera strains.
Until recently, only Vibrio cholerae strains of the O1 serogroup have been associated with epidemic cholera. In December 1992, an outbreak of cholera gravis in Vellore, India, was attributed to a newExpand
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Purification and characterization of a potent hemolytic toxin with phospholipase A2 activity from the venom of Indian Russell's viper
A potent toxin with phospholipase A2 (PLA2) and hemolytic activity in vitro was purified from the Russell's viper venom of eastern India (RVV-EI). The purified protein (RVV-PFIIc′) of 15.3 kDaExpand
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