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Shared ectomycorrhizal fungi between a herbaceous perennial (Helianthemum bicknellii) and oak (Quercus) seedlings
Summary • Ectomycorrhizal infection of Quercus seedlings can be low at a distance from established ectomycorrhizal vegetation. Here we investigate whether Helianthemum bicknellii , a herbaceousExpand
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  • Open Access
Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA
Endogenous 5-methylcytosine (MeC) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational ‘hotspots’ for smoking induced lung cancer. MeC enhances theExpand
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  • Open Access
Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids,Expand
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Isolation of Natural Products from Casearia nigrescens
Isolation of Natural Products from Casearia nigrescens
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  • Open Access
The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.
The important anticancer drug Taxol (paclitaxel) binds to tubulin in a stoichiometric ratio and promotes its assembly into microtubules. The conformation of microtubule-bound drug has been theExpand
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Density functional study of the influence of C5 cytosine substitution in base pairs with guanine
The present study employs density-functional electronic structure methods to investigate the effect of chemical modification at the C5 position of cytosine. A series of experimentally motivatedExpand
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Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest
Bioassay-directed fractionation of an extract of the root and bark of Podocarpus madagascariensis resulted in the isolation of a new totarol diterpenoid (1) in addition to the three known cytotoxicExpand
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Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest.
The new glycoresins, ipomoeassins A-E (1-5), have been isolated from the leaves of Ipomoea squamosa. The structures were elucidated by spectroscopic analyses and chemical transformations. TheExpand
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Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts.
All CG dinucleotides along exons 5-8 of the p53 tumor suppressor gene contain endogenous 5-methylcytosine ((Me)C, X = Me in Scheme 1). The same sites (e.g. p53 codons 157, 158, 245, 248, and 273) areExpand
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Effect of sequence context on the formation and repair of DNA adducts.
University of Minnesota Ph.D. dissertation. August 2009. Major: Biochemistry, Molecular Bio, and Biophysics. Advisor: Dr. Natalia Tretyakova. 1 computer file (PDF); xvi, 2002 pages.
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