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Predicting Skin Permeability
A facile interpretation of a considerable body of skin permeability measurements is presented that very adequately describes the dependence of Kp upon permeant size and lipophilicity, generates parameters of considerable physicochemical and mechanistic relevance, and implies that the SC lipids alone can fully characterize the barrier properties of mammalian skin. Expand
Epidermal barrier dysfunction in atopic dermatitis.
The strong association between both genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal barrier dysfunction is a primary event in the development of this disease. Expand
Iontophoretic drug delivery.
A comprehensive and critical review of the different therapeutic classes and molecules that have been investigated as potential candidates for iontophoretic delivery and the development of the first pre-filled, pre-programmed iontophile device, which is scheduled to be commercialized during the course of 2004. Expand
Passive skin penetration enhancement and its quantification in vitro.
Three different in vitro methods, specifically, classic diffusion cell studies, attenuated total-reflectance-Fourier transform infrared spectroscopy, and tape stripping in conjunction with an appropriate analytical technique, are considered, emphasizing their application to obtain quantitative values for skin transport parameters and to separate the kinetic or thermodynamic effects of an enhancement strategy. Expand
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.
Analysis has shown that the oral TTC values are valid for topical exposures and that the relationship between the external topical dose and the internal dose can be taken into account by conservative default adjustment factors. Expand
Skin penetration and distribution of polymeric nanoparticles.
Confocal laser scanning microscopy was used to visualize the distribution of non-biodegradable, fluorescent, polystyrene nanoparticles across porcine skin and revealed that these non-follicular structures did not offer an alternative penetration pathway for the polymer vectors, whose transport was clearly impeded by the stratum corneum. Expand
Plasma membrane poration induced by ultrasound exposure: implication for drug delivery.
It is confirmed that sonoporation is a means with which to achieve macromolecule delivery into cells, and the phenomenon of ultrasound induction of transient pores in the cell membrane is characterizes in some detail. Expand
Mathematical models of skin permeability: an overview.
An overview of various modeling approaches of skin permeability with respect to their advantages, limitations and future prospects is provided. Expand
A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond Activity
  • R. Potts, R. Guy
  • Chemistry, Medicine
  • Pharmaceutical Research
  • 1 November 1995
A biophysically relevant model of drug transport through human skin is derived based solely on the physical properties of the drug, which provides an algorithm to predict permeability from the drug's structure and/or physical properties. Expand
Modeling transdermal drug release.
  • Y. Kalia, R. Guy
  • Chemistry, Medicine
  • Advanced drug delivery reviews
  • 11 June 2001
This review describes the theoretical principles used to describe transdermal release and shows that relatively simple membrane transport models based on the appropriate solution to Fick's second law of diffusion can be used to explain drug release kinetics into this complex biological membrane. Expand