16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment
- R. Guerrero-Preston, F. Godoy-Vitorino, D. Sidransky
- Biology, MedicineOncoTarget
- 30 May 2016
Results suggest that microbiota may be used as HNSCC diagnostic and prognostic biomonitors and the relative abundance of OTU's within genus Streptococcus, Dialister, and Veillonella can be used to discriminate tumor from control samples.
Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission
- M. Loyo, R. Guerrero-Preston, D. Sidransky
- Medicine, BiologyInternational Journal of Cancer
- 15 June 2010
Results confirm that MCV is widespread in the human body and suggest a possible fecal‐oral transmission route similar to the Hepatitis A virus and appear that only neuroendocrine skin cells are susceptible to transformation by MCV.
Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy
The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation ofcancer treatment technologies by utilisation of another state of matter.
Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation
- Yiping Huang, R. Guerrero-Preston, E. Ratovitski
- Biology, ChemistryCell Cycle
- 15 March 2012
The data support the notion that the cisplatin-induced p-ΔNp63α could regulate key pathways implicated in response of cancer cells to chemotherapeutics.
Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer
- R. Guerrero-Preston, C. Michailidi, D. Sidransky
- 1 May 2014
An integrated molecular analysis based on methylation binding domain sequencing, whole exome sequencing, and whole genome gene expression arrays in primary head and neck squamous cell carcinoma tumors and matched uvulopalatopharyngoplasty tissue samples finds a high frequency of genomic and epigenomic alterations in the PAX gene family of transcription factors.
Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds
- R. Guerrero-Preston, L. Goldman, D. Sidransky
- 16 August 2010
This study supports the use of global DNA methylation status as a biomarker of in utero exposure to cigarette smoke and PFCs and shows an inverse dose response to serum cotinine levels.
A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA
Promoter methylation of a panel of 6 genes has potential for use as a biomarker for early cancer detection and to predict prognosis at the time of diagnosis.
High-resolution microbiome profiling uncovers Fusobacterium nucleatum, Lactobacillus gasseri/johnsonii, and Lactobacillus vaginalis associated to oral and oropharyngeal cancer in saliva from HPV…
- R. Guerrero-Preston, J. White, D. Sidransky
- 7 September 2017
High-resolution analyses on 583 samples suggest a possible role for bacterial species in the therapeutic outcome of HPV positive and HPV negative HNSCC patients.
Cold atmospheric plasma treatment selectively targets head and neck squamous cell carcinoma cells
- R. Guerrero-Preston, T. Ogawa, B. Trink
- Biology, MedicineInternational Journal of Molecular Medicine
- 11 July 2014
It is suggested that cold plasma application selectively impairs HNSCC cell lines through non-apoptotic mechanisms, while having a minimal effect on normal oral cavity epithelial cell lines.
NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva
- R. Guerrero-Preston, E. Soudry, D. Sidransky
- Medicine, BiologyCancer Prevention Research
- 10 May 2011
This phase I Biomarker Development Trial identified a panel of differentially methylated genes in normal and OSCC clinical samples from patients with heterogeneous risk profiles that may be useful for early detection and cancer prevention studies.