• Publications
  • Influence
The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000.
TLDR
Current estimates of the global burden of disease for diarrhoea are reported and compared with previous estimates made using data collected in 1954-79 and 1980-89, finding that the total morbidity component of the disease burden is greater than previously. Expand
Practice guidelines for the management of infectious diarrhea.
TLDR
Prevention by avoidance of undercooked meat or seafood, avoidance of unpasteurized milk or soft cheese, and selected use of available typhoid vaccines for travelers to areas where typhoid is endemic are key to the control of infectious diarrhea. Expand
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global
TLDR
The results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Expand
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic
TLDR
The challenge for governments and the health development community more broadly is to heed knowledge about the comparative effect of health risks, according to the World Health Organization. Expand
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic
TLDR
The Global Burden of Disease, Injuries, and Risk Factor study 2013 is the first of a series of annual updates of the GBD and six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. Expand
Enteroaggregative Escherichia coli.
TLDR
The pathogenesis of EAEC infection is not well understood, but a model can be proposed in which EAEC adhere to the intestinal mucosa and elaborate enterotoxins and cytotoxin, which result in secretory diarrhea and mucosal damage. Expand
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.
TLDR
Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Expand
Role of adherence in cytopathogenic mechanisms of Entamoeba histolytica. Study with mammalian tissue culture cells and human erythrocytes.
TLDR
Findings indicate that the adherence of E. histolytica to target cells requires microfilament function, is via a specific amebic receptor that has affinity for GALNAc, and is required to lyse cells. Expand
Cryptosporidiosis: an emerging, highly infectious threat.
  • R. Guerrant
  • Biology, Medicine
  • Emerging infectious diseases
  • 1997
TLDR
Treatment is very limited, new approaches that may reduce secretion or enhance repair of the damaged intestinal mucosa are under study and new methods such as those using polymerase chain reaction may help with detection of Cryptosporidium in water supplies or in asymptomatic carriers. Expand
Multi-country analysis of the effects of diarrhoea on childhood stunting.
TLDR
In this assembled sample of 24-month-old children, the proportion of stunting attributed to <or=5 diarrhoeal episodes before 24 months was 25% and that attributed to being ill with diarrhoea for >or=2% of the time before 24 years was 18%, consistent with the hypothesis that a higher cumulative burden of diarrhoeas increases the risk of Stunting. Expand
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