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The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord
The mechanisms controlling the transition from neurogenesis to gliogenesis in the vertebrate CNS are incompletely understood. We identified a family of transcription factors, called NFI genes, whichExpand
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Roles of the NFI/CTF gene family in transcription and development.
The Nuclear Factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of geneExpand
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Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis
Transcriptional cascades that operate over the course of lineage development are fundamental mechanisms that control cellular differentiation. In the developing central nervous system (CNS), theseExpand
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Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence.
The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction increases with aging. Although signaling pathways that promote NSC quiescence have been identified, theExpand
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Nfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle
Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcriptionExpand
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The Transcription Factor Gene Nfib Is Essential for both Lung Maturation and Brain Development
ABSTRACT The phylogenetically conserved nuclear factor I (NFI) gene family encodes site-specific transcription factors essential for the development of a number of organ systems. We showed previouslyExpand
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NFIA Haploinsufficiency Is Associated with a CNS Malformation Syndrome and Urinary Tract Defects
Complex central nervous system (CNS) malformations frequently coexist with other developmental abnormalities, but whether the associated defects share a common genetic basis is often unclear. WeExpand
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Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
The nuclear factor I (NFI) family of site‐specific DNA‐binding proteins is required for both the cell‐type specific transcription of many viral and cellular genes and for the replication ofExpand
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Abnormal Development of Forebrain Midline Glia and Commissural Projections in Nfia Knock-Out Mice
Nuclear factor I (NFI) genes are expressed in multiple organs throughout development (Chaudhry et al., 1997; for review, seeGronostajski, 2000). All four NFI genes are expressed in embryonic mouseExpand
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NFIA Controls Telencephalic Progenitor Cell Differentiation through Repression of the Notch Effector Hes1
The balance between self-renewal and differentiation of neural progenitor cells is an absolute requirement for the correct formation of the nervous system. Much is known about both the pathwaysExpand
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