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Factors associated with COVID-19-related death using OpenSAFELY
Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, and this requires new approachesExpand
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Trial of early, goal-directed resuscitation for septic shock.
BACKGROUND Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, andExpand
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OpenSAFELY: factors associated with COVID-19 death in 17 million patients
COVID-19 has rapidly affected mortality worldwide 1 . There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of largeExpand
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Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).
CONTEXT Extracorporeal membrane oxygenation (ECMO) can support gas exchange in patients with severe acute respiratory distress syndrome (ARDS), but its role has remained controversial. ECMO was usedExpand
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OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients.
Background Establishing who is at risk from a novel rapidly arising cause of death, and why, requires a new approach to epidemiological research with very large datasets and timely data. Working onExpand
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Health economics: an introduction to economic evaluation
The second edition of this guide to economic evaluation is significantly extended. This mirrors the development of economic evaluation since the first edition was published in 1996. The methodologyExpand
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Health benefits of antiviral therapy for mild chronic hepatitis C: randomised controlled trial and economic evaluation.
OBJECTIVES To determine whether combined therapy with interferon-alpha and ribavirin was more effective and cost-effective than no treatment for patients with mild chronic hepatitis C. DESIGN AExpand
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A randomized trial of hyperglycemic control in pediatric intensive care.
BACKGROUND Whether an insulin infusion should be used for tight control of hyperglycemia in critically ill children remains unclear. METHODS We randomly assigned children (≤16 years of age) whoExpand
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Non-parametric methods for cost-effectiveness analysis: the central limit theorem and the bootstrap compared.
Cost-effectiveness analyses (CEA) alongside randomised controlled trials commonly estimate incremental net benefits (INB), with 95% confidence intervals, and compute cost-effectiveness acceptabilityExpand
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Methods for covariate adjustment in cost-effectiveness analysis that use cluster randomised trials.
Statistical methods have been developed for cost-effectiveness analyses of cluster randomised trials (CRTs) where baseline covariates are balanced. However, CRTs may show systematic differences inExpand
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