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A constitutively open potassium channel formed by KCNQ1 and KCNE3
Mutations in all four known KCNQ potassium channel α-subunit genes lead to human diseases. KCNQ1 (KvLQT1) interacts with the β-subunit KCNE1 (IsK, minK) to form the slow, depolarization-activatedExpand
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Ion transport mechanisms in thick ascending limb of Henle's loop of mammalian nephron.
  • R. Greger
  • Chemistry, Medicine
  • Physiological reviews
  • 1 July 1985
  • 501
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Chemical probes for anion transporters of mammalian cell membranes.
Mammalian cell membranes harbor several types of chloride channels, chloride-cation symporters/cotransporters, and several classes of anion exchangers/antiporters. These transport systems subserveExpand
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Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidney
  • R. Greger
  • Chemistry, Medicine
  • Pflügers Archiv
  • 1 April 1981
The cation permeability of the cortical thick ascending limb of Henle's loop was investigated with electrophysiological methods in the isolated perfused tubule preparation of rabbit kidney. TheExpand
  • 152
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Cl−-channel blockers in the thick ascending limb of the loop of Henle Structure activity relationship
On the basis of our findings with diphenylamine-2-carboxylate [5] we have searched for compounds which possess an even higher affinity for the Cl−-channels in the basolateral membrane of the thickExpand
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Presence of luminal K+, a prerequisite for active NaCl transport in the cortical thick ascending limb of Henle's loop of rabbit kidney
Previous data from our laboratory have shown that active transport in the cortical thick ascending limb of Henle's loop (cTAL), as measured by the short circuit current (ISC, μA · cm−2), requires theExpand
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Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism.
Mineralocorticoid receptor (MR)-deficient mice were generated by gene targeting. These animals had a normal prenatal development. During the first week of life, MR-deficient (-/-) mice developedExpand
  • 363
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Role of CFTR in the colon.
  • R. Greger
  • Medicine, Biology
  • Annual review of physiology
  • 2000
In contrast to the airways, the defects in colonic function in cystic fibrosis (CF) patients are closely related to the defect in CFTR. The gastrointestinal phenotype of CF transgenic mice closelyExpand
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Physiology of renal sodium transport.
  • R. Greger
  • Medicine
  • The American journal of the medical sciences
  • 2000
A wealth of studies performed with a spectrum of methods spanning simple clearance studies to the molecular identification of ion transporters has increased our understanding of how approximately 1.7Expand
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The luminal K+ channel of the thick ascending limb of Henle's loop
In vitro perfused rat thick ascending limbs of Henle's loop (TAL) were used (n=260) to analyse the conductance properties of the luminal membrane applying the patch-clamp technique. Medullary (mTAL)Expand
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