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Correlates of sleep and waking in Drosophila melanogaster.
Drosophila rest is characterized by an increased arousal threshold and is homeostatically regulated independently of the circadian clock, which implicate the catabolism of monoamines in the regulation of sleep and waking in the fly. Expand
Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila.
Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has twoExpand
Stress response genes protect against lethal effects of sleep deprivation in Drosophila
The observation that flies carrying a mutation for the heat-shock protein Hsp83 showed exaggerated homeostatic response and died after sleep deprivation represents the first step in identifying the molecular mechanisms that constitute the sleep homeostat. Expand
Dopaminergic Modulation of Arousal in Drosophila
It is shown that changes in dopamine levels differentially affect arousal for behaviors of varying complexity, and that complex behaviors degenerate when dopamine levels are either too high or too low, in accordance with the inverted-U hypothesis of dopamine action in the mammalian brain. Expand
Courtship in Drosophila.
Results from different experimental approaches sketches the outlines of a set of pleiotropic genes acting on a distributed system in the brain to produce the species-specific sequence of responses and actions. Expand
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
It is shown in Drosophila melanogaster that both 5-HT and neuropeptide F, the invertebrate homolog of neuropePTide Y, modulate aggression, and the implication of these two modulatory systems in fly and mouse aggression suggest a marked degree of conservation and a deep molecular root for this behavior. Expand
Fly pushing : the theory and practice of Drosophila genetics
The basics of doing a cross isolating new variants mapping synthesizing specific genotypes analysis of mutations I - characteristics of the allele analysis of mutations II - mosiacs you're on yourExpand
Molecular analysis of flies selected for aggressive behavior
A population-based selection procedure to increase aggression in Drosophila melanogaster was developed and found that selection for increases in aggression can be used to molecularly dissect this behavior. Expand
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
It is demonstrated that rhomboid (Rho)- and Star-mediated activation of EGFR and ERK signaling increases sleep in a dose-dependent manner, and that blockade of rho expression in the nervous system decreases sleep. Expand
The Brain Activity Map Project and the Challenge of Functional Connectomics
A large-scale, international public effort is proposed, aimed at reconstructing the full record of neural activity across complete neural circuits, which could prove to be an invaluable step toward understanding fundamental and pathological brain processes. Expand