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Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis.
In the phosphorelay signal transduction system for sporulation initiation in Bacillus subtilis, the opposing activities of histidine kinases and aspartyl phosphate phosphatases determine the cell'sExpand
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A novel histidine kinase inhibitor regulating development in Bacillus subtilis.
Kinase A is the sensor histidine kinase responsible for processing postexponential phase information and providing phosphate input to the phosphorelay that activates developmental transcription viaExpand
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Disruption of the gene (spo0A) encoding sporulation transcription factor blocks endospore formation and enterotoxin production in enterotoxigenic Clostridium perfringens type A.
This study identified a functional spo0A ORF in enterotoxigenic Clostridium perfringens type A. To evaluate the function of spo0A, an isogenic spo0A knock-out mutant was constructed. The spo0A mutantExpand
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Bacillus subtilis biofilm extends Caenorhabditis elegans longevity through downregulation of the insulin-like signalling pathway
Beneficial bacteria have been shown to affect host longevity, but the molecular mechanisms mediating such effects remain largely unclear. Here we show that formation of Bacillus subtilis biofilmsExpand
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De novo fatty acid synthesis is required for establishment of cell type‐specific gene transcription during sporulation in Bacillus subtilis
A hallmark of sporulation of Bacillus subtilis is the formation of two distinct cells by an asymmetric septum. The developmental programme of these two cells involves the compartmentalized activitiesExpand
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Characterization of a novel inhibitory feedback of the anti‐anti‐sigma SpoIIAA on Spo0A activation during development in Bacillus subtilis
Compartmentalized gene expression during sporulation is initiated after asymmetric division by cell‐specific activation of the transcription factors σF and σE. Synthesis of these σ factors, and theirExpand
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Spo0A links de novo fatty acid synthesis to sporulation and biofilm development in Bacillus subtilis
During sporulation in Bacillus subtilis, the committed‐cell undergoes substantial membrane rearrangements to generate two cells of different sizes and fates: the mother cell and the forespore. Here,Expand
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DNA supercoiling and thermal regulation of unsaturated fatty acid synthesis in Bacillus subtilis
Bacillus subtilis growing at 37° C synthesizes, almost exclusively, saturated fatty acids. However, when a culture growing at 37°C is transferred to 20°C, the synthesis of unsaturated fatty acids isExpand
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Novel roles of the master transcription factors Spo0A and sigmaB for survival and sporulation of Bacillus subtilis at low growth temperature.
Spore development and stress resistance in Bacillus subtilis are governed by the master transcription factors Spo0A and sigma(B), respectively. Here we show that the coding genes for both regulatoryExpand
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Inorganic Phosphate Induces Spore Morphogenesis and Enterotoxin Production in the Intestinal Pathogen Clostridium perfringens
ABSTRACT Clostridium perfringens enterotoxin (CPE) is an important virulence factor for food poisoning and non-food borne gastrointestinal (GI) diseases. Although CPE production is strongly regulatedExpand
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