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Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to Eimeria maxima
TLDR
The most notable changes in the expression of immunoglobulins were a biphasic increase in the amount of IgM+‐staining in the course of primary infection (corresponding approximately to that of the T cells), and in IgA + cells shortly after challenge. Expand
Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice
TLDR
The data establish that the protective mechanism induced by administration of CpG ODN 1585 in the absence of parasite antigen is similar in nature to the mechanism inducing by immunization with radiation-attenuated P. yoelii antigens. Expand
Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.
TLDR
Data indicate that oligodeoxynucleotides containing CpG motifs improve immunogenicity of peptide immunogens in non-human primates, and may be immunopotentiators useful in humans. Expand
HLA-DR-Promiscuous T Cell Epitopes from Plasmodium falciparum Pre-Erythrocytic-Stage Antigens Restricted by Multiple HLA Class II Alleles1 2
TLDR
The identification of HLA class II degenerate T cell epitopes from P. falciparum validates the predictive strategy in a biologically relevant system and supports the potential for developing a broadly efficacious epitope-based vaccine against malaria focused on a limited number of peptide specificities. Expand
Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia.
TLDR
Good safety, tolerance, and efficacy, along with key advantages in dosing requirements, make primaquine an excellent drug for preventing malaria in nonpregnant, G6PD-normal travelers. Expand
Evidence linking programmed cell death in the blastocyst to polyamine oxidation.
TLDR
It is shown that an amine oxidase in the blastocyst oxidizes polyamines in blastocele fluid, generating hydrogen peroxide which causes programmed cell death of normal and malignant cells with trophectodermal potential. Expand
Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use.
TLDR
It is anticipated that optimization of multi-gene P. falciparum DNA vaccines designed to protect against malaria by inducing CD8+ T cells that target infected hepatocytes will require extensive clinical trials during the coming years. Expand
Route and Method of Delivery of DNA Vaccine Influence Immune Responses in Mice and Non-Human Primates
TLDR
Route of administration of plasmid DNA vaccines influences the strength and nature of immune responses in mice and non-human primates, however, the results in mice were not always predictive of those in monkeys and this is likely true for humans as well. Expand
Malaria DNA vaccines in Aotus monkeys.
TLDR
It is demonstrated in Aotus monkeys that an intradermal route of immunization with a PyCSP plasmid DNA vaccine generates antibody responses equivalent to a multiple antigen peptide/adjuvant based vaccine, and that these data support the use of the intrader mal route for initial studies of the efficacy of DNA vaccines. Expand
Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.
TLDR
Atovaquone/proguanil was well tolerated, safe, and effective for the prevention of drug-resistant P. vivax and P. falciparum malaria in individuals without prior malaria exposure who migrated to Papua, Indonesia. Expand
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