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Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia.
OBJECTIVE To use functional magnetic resonance imaging (fMRI) to evaluate the pattern of cerebral activation during the application of painful pressure and determine whether this pattern is augmentedExpand
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Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses
&NA; Psychophysical experiments were carried out on 6 human subjects to determine how first and second pain are influenced by peripheral receptor mechanisms and by central nervous system inhibitoryExpand
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Evidence of augmented central pain processing in idiopathic chronic low back pain.
OBJECTIVE For many individuals with chronic low back pain (CLBP), there is no identifiable cause. In other idiopathic chronic pain conditions, sensory testing and functional magnetic resonanceExpand
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The cortical representation of pain
Anatomical and physiological studies in animals, as well as functional imaging studies in humans have shown that multiple cortical areas are activated by painful stimuli. The view that pain isExpand
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Pain catastrophizing and neural responses to pain among persons with fibromyalgia.
Pain catastrophizing, or characterizations of pain as awful, horrible and unbearable, is increasingly being recognized as an important factor in the experience of pain. The purpose of thisExpand
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Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors.
OBJECTIVE Although the American College of Rheumatology (ACR) criteria for fibromyalgia are used to identify individuals with both widespread pain and tenderness, individuals who meet these criteriaExpand
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Amitriptyline, but not lorazepam, relieves postherpetic neuralgia
In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12.5 to 150 mg/d; lorazepam, 0.5 to 6 mg/d; or lactose placebo. DosesExpand
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Ratio scales of sensory and affective verbal pain descriptors
&NA; The results of two experiments show that ratio scales of sensory and affective verbal pain descriptors are valid, reliable and objective. In the first experiment, 16 subjects rated 15 sensoryExpand
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Painful neuropathy: altered central processing maintained dynamically by peripheral input
We performed sensory assessments before and during diagnostic tourniquet-cuff and local anesthetic blocks in 4 patients diagnosed with reflex sympathetic dystrophy (RSD). All patients complained ofExpand
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Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome.
OBJECTIVE Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are associated with substantial physical disability. Determinants of self-reported physical disability are poorly understood. ThisExpand
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