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Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause.
This model shows follicle numbers decline bi-exponentially rather than as a simple exponential function of age, as had been assumed, with a first exponential rate parameter of -0.097 and a second of - 0.237, and predicts the impact of step reductions of follicles numbers on the prospective span of menstrual life was predicted. Expand
Restoration of fertility to oophorectomized sheep by ovarian autografts stored at-196°C
Despite substantial depletion of primordial follicle numbers, the results indicated that frozen storage and replacement of a patient's own ovarian tissue might be practicable when fertility potential is threatened by chemotherapy/radiotherapy. Expand
Spermatogenesis and steroidogenesis in mouse, hamster and monkey testicular tissue after cryopreservation and heterotopic grafting to castrated hosts.
Results show that isografts and xenografteds of immature and adult testicular tissue become functionally active as a s.c. graft in the mouse and that this approach might be useful in combination with cryopreservation as a tool for storage and activation of the male germ line and androgen replacement therapy in patients. Expand
Low temperature storage and grafting of human ovarian tissue.
  • R. Gosden
  • Medicine, Biology
  • Molecular and cellular endocrinology
  • 1 July 1996
Ovarian tissue banking should still be regarded as an experimental procedure, though recent results indicate that it has clinical potential, and cryopreservation provides an opportunity for long-term preservation of oocytes. Expand
Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles.
This study shows for the first time that transcription of the FSHr gene begins at the earliest stages of follicular growth and indicates that FSH may have a hitherto unsuspected physiological role in preantral follicle development. Expand
Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue.
Primordial follicles can be isolated from fresh and cryopreserved human ovarian tissue with similar high efficiency and viability rates and Electron microscopy confirmed that the majority of the cells lacked ultrastructural signs of damage after isolation andCryopreservation. Expand
A model conforming the decline in follicle numbers to the age of menopause in women.
This study attempts to produce a biologically more realistic model of follicle disappearance and harmonizes follicle dynamics with the distribution of menopausal ages from an American survey and produces a stochastic threshold model for menopause which could be forecast with an acceptable margin of uncertainty. Expand
Rare congenital disorders, imprinted genes, and assisted reproductive technology
Three recent studies all report an unexpectedly high incidence of Beckwith-Wiedemann syndrome (BWS) in children conceived with ARTs. Expand
The molecular basis of oocyte growth and development
Throughout oocyte development follicle cell support is fundamental to provide the germ line cell with nutrients and growth regulators to ensure progression through the protracted growth phase, and the oocyte actively promotes growth and differentiation of the follicular cells. Expand
Follicular development from ovarian xenografts in SCID mice.
It is demonstrated that ovarian xenografts in SCID mice can serve as experimental models for investigating follicle development in species in which follicle growth in vitro and studies of the parent animal are impracticable. Expand