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Role of oxygen in arteriolar functional vasodilation in hamster striated muscle.
Small isolated groups of striated muscle cells were stimulated in the hamster cremaster muscle. During and after stimulation, oxygen microelectrodes were employed to determine the relationships amongExpand
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Interrelations between contracting striated muscle and precapillary microvessels.
Arterioles and capillaries in the hamster cremaster muscle were observed during electrical stimulation of striated muscle fibers in order to characterize the microcirculatory basis of functionalExpand
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Augmented Tissue Oxygen Supply during Striated Muscle Contraction in the Hamster: Relative Contributions of Capillary Recruitment, Functional Dilation, and Reduced Tissue PO2
To investigate the relative contributions of alterations in blood flow, capillary density, and tissue PO2 to elevated oxygen delivery in working muscle, we conducted experiments on the suffusedExpand
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Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors*
Postnatal cardiac myocytes respond to stress signals by hypertrophic growth and activation of a fetal gene program. Recently, we showed that class II histone deacetylases (HDACs) suppress cardiacExpand
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Pharmacology of ASL‐8052, a Novel β-Adrenergic Receptor Antagonist with an Ultrashort Duration of Action
Summary ASL-8052, a novel β-adrenergic receptor antagonist, was studied in isolated guinea pig cardiac and tracheal tissues, in isolated frog sciatic nerves, and in anesthetized dogs. The compoundExpand
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Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.
Several short-acting beta-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems. In particular,Expand
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Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of hepatic uptake and efflux transporters inExpand
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Rationale and design of the enoximone clinical trials program.
BACKGROUND Chronic heart failure is a disease syndrome characterized in its advanced stages by a poor quality of life, frequent hospitalizations, and a high risk of mortality. In advanced andExpand
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Reduced nitric oxide reactivity of a new recombinant human hemoglobin attenuates gastric dysmotility.
The objective of this investigation was to compare the gastric motility effects of two recombinant hemoglobin variants, rHb1.1, and rHb3011, the latter having decreased nitric oxide reactivity viaExpand
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Beta-adrenoreceptor antagonist potency and pharmacodynamics of ASL-8123, the primary acid metabolite of esmolol.
The beta-adrenoreceptor antagonist properties of ASL-8123, the primary metabolite of esmolol, were determined in vitro and in vivo. ASL-8123 demonstrated weak competitive beta-adrenoreceptor blockingExpand
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