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Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts
The results suggest that discrimination of monocytes, macrophages, fibrocytes, and fibroblasts in fibrotic lesions is possible, and this may allow for an assessment of fibroCytes in Fibrotic diseases. Expand
The Discovery and Broadband Follow-up of the Transient Afterglow of GRB 980703
We report on the discovery of the radio, infrared, and optical transient coincident with an X-ray transient proposed to be the afterglow of GRB 980703. At later times when the transient has fadedExpand
Inhibition of Fibrocyte Differentiation by Serum Amyloid P 1
It is found that CD14+ peripheral blood monocytes cultured in the absence of serum or plasma differentiate into fibrocytes within 72 h, and results suggest that low levels of SAP may augment pathological processes leading to fibrosis, and mechanisms to inhibit fibrosis in chronic inflammatory conditions, or conversely to promote wound healing. Expand
Overexpression of White Collar‐1 (WC‐1) activates circadian clock‐associated genes, but is not sufficient to induce most light‐regulated gene expression in Neurospora crassa
It is suggested that White Collar‐1 can mediate both light and circadian responses, with an increase in WC‐1 levels affecting circadian clock‐responsive gene regulation and other features ofWC‐1, possibly its phosphorylation, affecting light‐ responsive gene regulation. Expand
Multiple oscillators regulate circadian gene expression in Neurospora
The predicted or known functions of the clock-controlled genes demonstrate that the clock contributes to a wide range of cellular processes, including cell signaling, development, metabolism, and stress responses. Expand
Pivotal Advance: Th‐1 cytokines inhibit, and Th‐2 cytokines promote fibrocyte differentiation
It is found that when added to human PBMCs cultured in serum‐free medium, the profibrotic cytokines IL‐4 and IL‐13 promote fibrocyte differentiation without inducing fibroicyte or fibroCyte precursor proliferation. Expand
Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice
The data suggest that SAP interferes with assumption of a fibroblast phenotype in a subset of monocytes and that SAP may be an important regulator in the linkage between inflammation and nonadaptive fibrosis in the heart. Expand
Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum
Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show aExpand
Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein
The sustained level of Dd-ras protein in prestalk cells suggests an additional role during differentiation, and corroborates other reports suggesting a possible function during cell growth. Expand