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HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study
TLDR
HIV infection is associated with a significantly decreased risk of developing MS and mechanisms of this observed possibly protective association may include immunosuppression induced by chronic HIV infection and antiretroviral medications. Expand
Autoimmune disease preceding amyotrophic lateral sclerosis
TLDR
There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. Expand
Differential risks of cancer types in people with Parkinson's disease: a national record-linkage study.
TLDR
This is the first study to report an association between PD and elevated rates of uterine and renal cancer, and corroborate the findings of a reduced risk for the development of cancers in PD patients shown in smaller studies. Expand
Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies
TLDR
These two databases show that patients with some immune-mediated diseases have an increased risk of TB, although one cannot explicitly state the direction of risk or exclude confounding, and may aid TB screening, control and treatment policies. Expand
Psychiatric disorders prior to amyotrophic lateral sclerosis
TLDR
Hospitalization with a diagnosis of schizophrenia, bipolar disorder, depression, or anxiety was significantly associated with a first diagnosis of ALS within the following year, likely to specifically reflect the clinicopathological overlap of ALS with frontotemporal dementia. Expand
COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England
TLDR
The reduced number of admissions during this period is likely to have resulted in increases in out-of-hospital deaths and long-term complications of myocardial infarction and missed opportunities to offer secondary prevention treatment for patients with coronary heart disease. Expand
ASSOCIATIONS BETWEEN AGE-RELATED MACULAR DEGENERATION, OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS: Record Linkage Study
TLDR
Age-related macular degeneration and arthritis are degenerative aging conditions that share some disease mechanisms and extracellular matrix involvement, however, considering arthritis after AMD, they are not positively associated. Expand
Associations between obstructive sleep apnoea, primary open angle glaucoma and age-related macular degeneration: record linkage study
TLDR
Although plausible mechanisms exist to consider a link between OSA and POAG, the two conditions are not positively associated, and by contrast, OSA is positively associated with AMD. Expand
Associations between age-related macular degeneration, Alzheimer disease, and dementia: record linkage study of hospital admissions.
TLDR
The data suggest that patients in England with dementia may be substantially less likely to receive AMD treatment, and further research is required to determine whether people with dementia receive appropriate investigation and treatment for AMD. Expand
Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies
TLDR
The findings strongly support the suggestion that patients with some immune-mediated diseases have an increased risk of SAH. Expand
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