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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used forExpand
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Generation of pluripotent stem cells from patients with type 1 diabetes
  • R. Maehr, S. Chen, +5 authors D. Melton
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 15 September 2009
Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated fromExpand
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Research Paper: A Randomized Trial Comparing Telemedicine Case Management with Usual Care in Older, Ethnically Diverse, Medically Underserved Patients with Diabetes Mellitus: 5 Year Results of the
We examine the effectiveness of a telemedicine intervention to achieve clinical management goals in older, ethnically diverse, medically underserved patients with diabetes. Expand
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Rituximab, B-lymphocyte depletion, and preservation of beta-cell function.
BACKGROUND The immunopathogenesis of type 1 diabetes mellitus is associated with T-lymphocyte autoimmunity. However, there is growing evidence that B lymphocytes play a role in manyExpand
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Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause life-threatening disorders. Here we explore the use of nuclear genome transfer between unfertilized oocytesExpand
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Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP).
Abstract Underutilization of glucose data and lack of easy and standardized glucose data collection, analysis, visualization, and guided clinical decision making are key contributors to poor glycemicExpand
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Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses.
CRH is synthesized in the hypothalamus and released in response to stress into the portal hypophyseal blood; an additional site of synthesis, the placenta, is present only during pregnancy. PlacentalExpand
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Periodontal changes in children and adolescents with diabetes: a case-control study.
OBJECTIVE To evaluate the level of oral disease in children and adolescents with diabetes. RESEARCH DESIGN AND METHODS Dental caries and periodontal disease were clinically assessed in 182 childrenExpand
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Research Paper: A Randomized Trial Comparing Telemedicine Case Management with Usual Care in Older, Ethnically Diverse, Medically Underserved Patients with Diabetes Mellitus
We found that diabetes case management delivered using telemedicine improved glycemic control, blood pressure, and LDL cholesterol levels in older patients with diabetes mellitus at one year of follow-up compared to usual care. Expand
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11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls
Type 2 vesicular monoamine transporter (VMAT2), found in the brain, is also expressed by β-cells of the pancreas in association with insulin. Preclinical experiments suggested thatExpand
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