• Publications
  • Influence
Global Illness and Deaths Caused by Rotavirus Disease in Children
The tremendous incidence of rotavirus disease underscores the urgent need for interventions, such as vaccines, to prevent childhood deaths in developing nations. Expand
Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens.
A PCR typing method was devised in which each human serotype virus produced a characteristic segment size, readily identifiable in agarose gels, which provided a rapid and efficient means of obtaining large quantities of cDNA suitable for sequencing, cloning, and other genetic studies, precluding the need for cell culture and virus purification. Expand
Identification of group A rotavirus gene 4 types by polymerase chain reaction.
The results suggest that gene 4 typing will be useful in providing more a complete characterization of HRV strains of epidemiologic or vaccine-related interest. Expand
Grand challenges in global mental health
A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action andExpand
Norovirus classification and proposed strain nomenclature.
Analyses of the pairwise distances demonstrated three clearly resolved peaks, suggesting that NoV strains beneath the species level can be classified at three levels: strain (S), cluster (C), and genogroup (G). Expand
Rotavirus and Severe Childhood Diarrhea
Application of this proportion to the recent World Health Organization estimates of diarrhea-related childhood deaths gave an estimated 611,000 rotavirus-related deaths. Expand
The magnitude of the global problem of diarrhoeal disease: a ten-year update.
In order to update global estimates of diarrhoeal morbidity and mortality in developing countries, we carried out a review of articles published from 1980 to the present and calculated medianExpand
Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis
Noroviruses accounted for 12% of severe gastroenteritis cases among children <5 years of age and 10% among children under the age of five, according to World Health Organization data. Expand
Typing of human astroviruses from clinical isolates by enzyme immunoassay and nucleotide sequencing.
A typing enzyme immunoassay (TYPE-EIA) was used to determine the antigenic types of 64 astrovirus-positive specimens from nine collections from seven countries, finding most strains of the same type were identical. Expand
Rotavirus infection in infants as protection against subsequent infections.
In infants, natural rotavirus infection confers protection against subsequent infection, which increases with each new infection and reduces the severity of the diarrhea. Expand