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Synuclein activates microglia in a model of Parkinson's disease
Parkinson's disease (PD) is the most common neurodegenerative movement disorder afflicting >500,000 patients in the United States alone. This age-related progressive disorder is typified by invariantExpand
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Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.
The rostral ventrolateral medulla is the primary site of action for clonidine, a centrally acting antihypertensive. In the rostral ventrolateral medulla, clonidine binds not only to alpha-2Expand
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Anatomical substrates of cholinergic‐autonomic regulation in the rat
Acetylcholine (ACh) plays a major role in central autonomic regulation, including the control of arterial blood pressure (AP). Previously unknown neuroanatomic substrates of cholinergic ‐ autonomicExpand
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Cardiovascular control by cholinergic mechanisms in the central nervous system.
Despite an extensive research effort over the last few decades, under­ standing of how the central nervous system (CNS)! controls the circulation is at best still incomplete. Many symposia andExpand
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Development of mRNAs for glucocorticoid and mineralocorticoid receptors in rat hippocampus.
The hippocampus plays an important role in mediating glucocorticoid effects on the brain. Glucocorticoids are also implicated in neurogenesis and age-related neuronal death in the hippocampus. TheExpand
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Hypotensive action of clonidine analogues correlates with binding affinity at imidazole and not alpha‐2-adrenergic receptors in the rostral ventrolateral medulla
Clonidine acts within the rostral ventrolateral medulla to lower arterial pressure. The receptor mechanism for this action is unknown. In the rostral ventrolateral medulla clonidine binds not only toExpand
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Ultrastructural localization and afferent sources of corticotropin‐releasing factor in the rat rostral ventrolateral medulla: Implications for central cardiovascular regulation
We investigated the ultrastructural localization, afferent sources, and arterial pressure effects of corticotropin‐releasing factor (CRF) in the nucleus reticularis rostroventrolateralis (RVL), aExpand
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Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla
In anesthetized, paralyzed rats intravenous administration of the acetylcholinesterase inhibitor physostigmine (PHY) (100 micrograms/kg) evoked a dose-related rise in arterial pressure (AP) and heartExpand
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Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
Development of effective antitumor immune responses depends on timely interactions of effector cells. A bimodal approach that involves coexpression of chemokines and costimulatory molecules withinExpand
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VIP is a transcriptional target of Nurr1 in dopaminergic cells
The orphan nuclear receptor Nurr1 is required for the development of the ventral mesencephalic dopaminergic neurons. These are the same neurons that are invariantly lost in patients with Parkinson'sExpand
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