R. Gingell

Publications69
h-index25
Citations1,824
Highly Influential Citations64
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Long-term potentiation in the interpositus and vestibular nuclei in the rat
SummaryPrevious unpublished experiments from this laboratory had revealed only post-activation depression effects in the cerebellar cortex when its inputs were activated by high frequency trains. In… Expand
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Two-Generation Reproduction Study and Immunotoxicity Screen in Rats Dosed with Phenol via the Drinking Water
This study evaluated the potential reproductive toxicity of phenol in a rat two-generation reproduction study, which included additional study endpoints, such as sperm count and motility,… Expand
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Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.
It is proposed that metabolism of several structurally-related chemicals by CYP2F isoforms of the cytochromes P450 family results in a cytotoxicity-driven mode of action in organs high in CYP2F;… Expand
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The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat.
1. The urinary excretion of total sulphanilamide (free and acetylated) in rats receiving Prontosil or Neoprontosil orally is considerably reduced when the rats are treated with antibiotics to… Expand
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Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F1 mice.
2-Ethylhexanol (2EH) is a weak nongenotoxic hepatic peroxisome proliferator in the rat. It is a high-volume chemical intermediate in the preparation of the plasticizers bis-(2-ethylhexyl) adipate… Expand
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Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites.
Ethylene glycol (CAS RN 107-21-1) can cause kidney toxicity via the formation of calcium oxalate crystals in a variety of species, including humans. Numerous repeated dose studies conducted in rats… Expand
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Prechronic toxicity studies on 2-ethylhexanol in F334 rats and B6C3F1 mice.
Data on the subchronic toxicity of 2-ethylhexanol (2EH) were required to establish the dose vehicle and dose levels for oncogenicity studies. In preliminary studies 2EH was given subacutely (11 days)… Expand
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Oncogenicity Testing of 2-Ethylhexanol in Fischer 344 Rats and B6C3F1 Mice
2-Ethylhexanol (2EH) is a weak nongenotoxic hepatic peroxisome proliferator in the rat. It is a high-volume chemical intermediate in the preparation of the plasticizers bis-(2-ethylhexyl) adipate… Expand
  • 18
  • 3
Mechanisms of azo reduction by Streptococcus faecalis. I. Optimization of assay conditions.
1. A new method for the assay of azo-reductase activity in Streptococcus faecalis and several other microbial species is reported. The assay is continuous and permits a more rapid and accurate… Expand
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Long-term results after excision of fixed subaortic stenosis.
Forty-nine patients underwent surgical excision of fixed subaortic stenosis (discrete fibrous ring and tunnel) between 1968 and 1984 and were followed up for 1 to 16 years (5.8 +/- 4). Twenty-six… Expand
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