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Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p
Temperature-sensitive mutations in the SEC16 gene of Saccharomyces cerevisiae block budding of transport vesicles from the ER. SEC16 was cloned by complementation of the sec16-1 mutation and encodesExpand
Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations,
Molecular, biochemical and functional data provide an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. Expand
Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis
Observations suggest that UCPH, like UCP, uncouples oxidative phosphorylation and the possibility that the U CPH protein is an important mediator of human thermogenesis is discussed. Expand
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin
Results suggest that CTRP9, a novel secreted glycoprotein from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin, is a novel adipokine. Expand
Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
These findings identify GPAT3 as a previously uncharacterized triacylglycerol biosynthetic enzyme that may be useful as a target for the treatment of obesity. Expand
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages
The interlinkage between the myocyte and the brown preadipocyte confirms the distinct origin for brown versus white adipose tissue and also represents a plausible explanation as to why brown adipocytes ultimately specialize in lipid catabolism rather than storage, much like oxidative skeletal muscle tissue. Expand
LST1 Is a SEC24 Homologue Used for Selective Export of the Plasma Membrane ATPase from the Endoplasmic Reticulum
Findings suggest that a specialized form of the COPII coat subunit, with Lst1p in place of Sec24p, is used for the efficient packaging of Pma1p into vesicles derived from the ER. Expand
COPII Subunit Interactions in the Assembly of the Vesicle Coat*
An important functional interaction between Sec16p and Sec31p is demonstrated and it is proposed thatSec16p organizes the assembly of a coat that is stabilized both by the interaction ofSec31p with Sec23p andSec24p and by the interactions of these three components with Sec16P. Expand
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.
It is shown that deletion of FGFR1 in fat (FR1KO) leads to a complete ablation of FGF21 stimulated transcriptional activity in this tissue, revealing the existence of an adiposeFGFR1 driven axis of cross-tissue communication which defines several aspects of F GF21 biology and delineates mechanistic distinctions between FGF 21 and FGF19. Expand
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500290-JLR200
The data support distinct functions for Adiponutrin and Desnutrin/ATGL and raise the possibility that GS2 may contribute significantly to lipolysis in human adipose tissue. Expand